Search results

• 2024

  A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations

  Anderson, M. A. E., Gonzalez, E., Edgington, M. P., Ang, J. X. D., Purusothaman, D. K., Shackleford, L., Nevard, K., Verkuijl, S. A. N., Harvey-Samuel, T., Leftwich, P. T., Esvelt, K. & Alphey, L., 25 Jan 2024, In: Nature Communications. 15, 729.

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  5 Citations (Scopus)

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• A synthetic biology approach to transgene expression in insects

  Leftwich, P. T., Purcell, J. C., Anderson, M. A. E., Fragkoudis, R., Basu, S., Lycett, G. & Alphey, L., 20 Sep 2024, In: ACS Synthetic Biology. 13, 9, p. 3041–3045 5 p.

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• Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata

  Meccariello, A., Hou, S., Davydova, S., Fawcett, J. D., Siddall, A., Leftwich, P. T., Krsticevic, F., Papathanos, P. A. & Windbichler, N., 8 Jan 2024, In: Nature Communications. 15, 372.

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• 2023

  Accentuating the positive and eliminating the negative: Efficacy of TiO₂ as digestibility index marker for poultry nutrition studies

  Sprigg, C., Leftwich, P. T., Burton, E., Scholey, D., Bedford, M. R. & Brearley, C. A., 26 Jun 2023, In: PLoS One. 18, 6, e0284724.

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• AePUb promoter length modulates gene expression in Aedes aegypti

  Anderson, M. A. E., Leftwich, P. T., Wilson, R., Carabajal Paladino, L. Z., Basu, S., Rooney, S., Adelman, Z. N. & Alphey, L., 21 Nov 2023, In: Scientific Reports. 13, 20352.

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• CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus

  Harvey-Samuel, T., Feng, X., Okamoto, E. M., Purusothaman, D-K., Leftwich, P. T., Alphey, L. & Gantz, V. M., 20 Nov 2023, In: Nature Communications. 14, 7561.

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• Optimizing CRE and PhiC31 mediated recombination in Aedes aegypti

  Carabajal Paladino, L. Z., Wilson, R., Tng, P. Y. L., Dhokiya, V., Keen, E., Cuber, P., Larner, W., Rooney, S., Nicholls, M., Uglow, A., Williams, L., Anderson, M. A. E., Basu, S., Leftwich, P. T. & Alphey, L., 22 Sep 2023, In: Frontiers in Bioengineering and Biotechnology. 11, 1254863.

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• 2022

  Characterisation of the symbionts in the Mediterranean fruit fly gut

  Darrington, M., Leftwich, P. T., Holmes, N. A., Friend, L. A., Clarke, N. V. E., Worsley, S. F., Margaritopolous, J. T., Hogenhout, S. A., Hutchings, M. I. & Chapman, T., 21 Apr 2022, In: Microbial Genomics. 8, 4, 000801.

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  5 Citations (Scopus)

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• Manipulating insect sex determination pathways for genetic pest management: Opportunities and challenges

  Siddall, A., Harvey-Samuel, T., Chapman, T. & Leftwich, P. T., 28 Jun 2022, In: Frontiers in Bioengineering and Biotechnology. 10, 867851.

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  9 Citations (Scopus)

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• Toward a CRISPR-Cas9-based gene drive in the diamondback moth Plutella xylostella

  Xu, X., Harvey-Samuel, T., Siddiqui, H. A., Ang, J. X. D., Anderson, M. E., Reitmayer, C. M., Lovett, E., Leftwich, P. T., You, M. & Alphey, L., Apr 2022, In: The CRISPR Journal. 5, 2, p. 224-236 13 p.

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• 2021

  Engineered expression of the invertebrate‐specific scorpion toxin AaHIT reduces adult longevity and female fecundity in the diamondback moth Plutella xylostella

  Harvey‐Samuel, T. D., Xu, X., Lovett, E., Dafa'alla, T., Walker, A., Norman, V. C., Carter, R., Teal, J., Akilan, L., Leftwich, P. T., Reitmayer, C. M., Siddiqui, H. A. & Alphey, L., Jul 2021, In: Pest Management Science. 77, 7, p. 3154-3164 11 p.

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  6 Citations (Scopus)

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• Genetic pest management and the background genetics of release strains

  Leftwich, P. T., Spurgin, L. G., Harvey-Samuel, T., Thomas, C. J. E., Paladino, L. C., Edgington, M. P. & Alphey, L., 15 Feb 2021, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 376, 1818, 20190805.

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  18 Citations (Scopus)

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• The Bioinformatics Virtual Coordination Network: An open-source and interactive learning environment

  Tully, B. J., Buongiorno, J., Cohen, A. B., Cram, J. A., Garber, A. I., Hu, S. K., Krinos, A. I., Leftwich, P. T., Marshall, A. J., Sieradzki, E. T., Speth, D. R., Suter, E. A., Trivedi, C. B., Valentin-Alvarado, L. E., Weissman, J. L. & BVCN Instructor Consortium, 14 Oct 2021, In: Frontiers in Education. 6, 711618.

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• 2020

  Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression

  Tng, P. Y. L., Paladino, L. C., Verkuijl, S. A. N., Purcell, J., Merits, A., Leftwich, P. T., Fragkoudis, R., Noad, R. & Alphey, L., Dec 2020, In: Communications Biology. 3, 413.

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  21 Citations (Scopus)

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• Expanding the CRISPR toolbox in Culicine mosquitoes: in vitro validation of Pol III promoters

  Anderson, M., Purcell, J., Verkuijl, S., Norman, V., Leftwich, P., Harvey-Samuel, T. & Alphey, L., 20 Mar 2020, In: ACS Synthetic Biology. 9, 3, p. 678-681 4 p.

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  20 Citations (Scopus)

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• Transmission efficiency drives host–microbe associations

  Leftwich, P. T., Edgington, M. P. & Chapman, T., 9 Sep 2020, In: Proceedings of the Royal Society B: Biological Sciences. 287, 1934, 20200820.

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• 2019

  Contribution of maternal effects to dietary selection in Mediterranean fruit flies

  Leftwich, P. T., Nash, W. J., Friend, L. A. & Chapman, T., Feb 2019, In: Evolution. 73, 2, p. 278-292

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  4 Citations (Scopus)

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• 2018

  Testing for assortative mating by diet in Drosophila melanogaster

  Leftwich, P. T. & Chapman, T., 20 Oct 2018, In: BIO-Protocol. 8, 20, e3057.

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• 2017

  Adaptation to divergent larval diets in the medfly, Ceratitis capitata

  Leftwich, P. T., Nash, W. J., Friend, L. A. & Chapman, T., Feb 2017, In: Evolution. 71, 2, p. 289–303

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  18 Citations (Scopus)

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• Gut microbiomes and reproductive isolation in Drosophila

  Leftwich, P., Clarke, N., Hutchings, M. & Chapman, T., 28 Nov 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 48, p. 12767-12772 6 p.

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  63 Citations (Scopus)

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• Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts

  Longdon, B., Day, J. P., Schulz, N., Leftwich, P. T., de Jong, M. A., Breuker, C. J., Gibbs, M., Obbard, D. J., Wilfert, L., Smith, S. C. L., McGonigle, J. E., Houslay, T. M., Wright, L. I., Livraghi, L., Evans, L. C., Friend, L. A., Chapman, T., Vontas, J., Kambouraki, N. & Jiggins, F. M., 25 Jan 2017, In: Proceedings of the Royal Society B: Biological Sciences. 284, 1847, 20162381.

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  31 Citations (Scopus)
• 2016

  Evolutionary biology and genetic techniques for insect control

  Leftwich, P., Bolton, M. & Chapman, T., Jan 2016, In: Evolutionary Applications. 9, 1, p. 212-230 19 p.

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• 2014

  Genetic elimination of field-cage populations of Mediterranean fruit flies

  Leftwich, P. T., Koukidou, M., Rempoulakis, P., Gong, H-F., Zacharopoulou, A., Fu, G., Chapman, T., Economopoulos, A., Vontas, J. & Alphey, L., 7 Oct 2014, In: Proceedings of the Royal Society B: Biological Sciences. 281, 1792, 20141372.

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• 2012

  Variation in adult sex ratio alters the association between courtship, mating frequency and paternity in the lek-forming fruitfly Ceratitis capitata: Sex ratio and male reproductive success in the Mediterranean Fruitfly

  Leftwich, P. T., Edward, D. A., Alphey, L., Gage, M. J. G. & Chapman, T., 1 Sep 2012, In: Journal of Evolutionary Biology. 25, 9, p. 1732-1740

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  27 Citations (Scopus)