In the Taylor lab, we are interested in biological resilience – the ways in which cells and organisms maintain homeostasis when faced with physiological and environmental challenge. Resilience is key to the survival of individuals and species, and is also one of the key properties lost during the ageing process.

We aim to:

1. Identify novel pathways that mediate resistance and adaptation to physiological and environmental stress
2. Understand how pathways that promote resilience are coordinated throughout organisms
3. Explore the relationship between ageing and resilience – how ageing affects pathways that mediate stress resistance, and in turn, how manipulation of these pathways can influence the ageing process

Our primary focus is on pathways that maintain homeostasis in the secretory pathway, which acts as a central nexus of homeostatic regulation and as a conduit for communication between cells. Ultimately, we aim to identify targets for therapies that will address the loss of resilience and diseases of homeostatic dysregulation associated with ageing.