Projects per year
Personal profile
Academic Background
Rose is an active research member of HealthUEA, and two of the Norwich Medical School's research centres: Lifespan Health and Metabolic Health. She is a member of the Nutrition and Preventive Medicine group and Norwich Institute for Healthy Ageing.
Biography
Rose obtained her BSc (Hons) in Biomedical Sciences in 2004 and was awarded the Fahrenheit Placement Prize for Excellence. She spent a year in industry with Pfizer Ltd, and in 2008 was awarded a PhD in Molecular Biology from UEA. Her post-doctoral research spanned 12 years in the BioMedical Research Centre at UEA. In 2020, was seconded for 20 months during the COVID-19 pandemic to develop an award winning clinical molecular diagnostics laboratory in collaboration with the Norfolk and Norwich University Hospital Foundation Trust to provide extra capacity for Pillar 1 testing. This collaboration was in partnership with the Quadram Institute for Bioscience, and collborated with the COVID-19 Genomics UK Consortium. Rose was also a leading member of The Norwich Testing Initiative working in partnership with The Earlham Institute.
Research Interests
Her research interests centre on understanding the molecular mechanisms underlying joint tissue homeostasis and how dietary phytochemicals might interact with these to promote musculoskeletal health and prevent disease. Rose has special interests in Osteoarthritis and Dupuytren’s disease.
Rose collaborates with partners across the Norwich Research Park, local hospitals, and further afield to bring cross disciplinary skills together for a holistic research approach. Her major research contributions follow a translational path from lab bench to clinical intervention trial. She has published key papers on the molecular mechanisms of sulforaphane in chondrocytes and cartilage, synergistic activity with other bioactives, identifying sulforaphane in the joint tissues following dietary consumption, and impact on synovial fluid proteome. This led to the BRoccoli In Osteoarthritis (BRIO) Study that looks at pain outcomes in osteoarthritis patients.
Current research interests:
- The impact of dietary sulforaphane on musculoskeletal health.
- The development of high-throughput in vitro screening methods (dietary phytochemical function discovery).
- The inhibition of MMP-14 as a viable therapeutic in Dupuytren’s Disease.
Rose is currently accepting PhD students. Please get in touch if you would like to chat about a project.
Current and upcoming research and PhD project opportunities:
- The Role of Broccoli Bioactives in Osteoarthritis (EDESIA)
- The Impact of a Plant-Rich Diet on Osteoarthritis during Menopause
- Cultivating Joint Health: Unveiling the Remarkable Potential of Plant Bioactives in Tackling Osteoarthritis.
- Investigating the influence of vitamin D in cells of the joint and their regulation of the extracellular matrix.
- Dupuytren’s Disease: Harnessing cutting-edge technologies to understand how genetic variants lead to clinically relevant changes in cellular phenotype.
Teaching
Rose teaches on the MB BS medical degree:
- Gateway Self Selected Component- Nutrition Theme Lead
- Gateway Further Biology for Medicine - Lecturer
- Year 2 Dietary Aspects of Anaemia - Lecturer
- Year 3 Medical Research Theme - Module Lead
- Year 4 Medical Elective - Tutor.
Rose is a PhD research supervisor, PhD mentor for the EDESIA PhD program and supervises BSc Biomedicine UG final year lab-based research dissertation projects.
Key Responsibilities
- NIHR/Versus Arthritis UK MSK TRC CMC Subtheme Lead for 'Maintaining joint health, preventing progression, and promoting regeneration'.
- Norwich Research Park Biorepository Access Committee (member)
- UEA Human Tissue Committee (member)
- UEA Human Tissue Sub Committee (member)
- UEA/MED Promotions Committee (observer)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Metalloproteinase Gene Expression and its Control In Osteoarthritis, University of East Anglia
Award Date: 1 Oct 2008
Bachelor of Biomedical science, Sheffield Hallam University
Award Date: 1 Aug 2004
Keywords
- Nutrition & Preventive Medicine
- Biochemistry
- Healthy Aging
Collaborations and top research areas from the last five years
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Dietary Screening Bioactives in Arthritis (DISCOVER) Platform
Action Arthritis (Norwich Hip Trust)
31/08/24 → 31/08/25
Project: Research
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Dietary Screening Bioactives in Arthritis (DISCOVER) Platform
Clark, I., Davidson, R., Macgregor, A. & Jupp, O.
The Kennedy Trust for Rheumatology Research
3/04/24 → 2/10/25
Project: Research
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Identifying the Dietary Signatures of Arthritis through metabolomics (the DeSignA study)
Macgregor, A., Clark, I., Davidson, R., Kemsley, K., Le Gall, G., Yates, M. & Chipping, J.
1/05/23 → 30/04/25
Project: Research
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Establishing inhibition of MMP-14 as a viable therapeutic in Dupuytren’s Disease
Action Arthritis (Norwich Hip Trust)
1/11/21 → 31/10/24
Project: Research
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Establishing inhibition of MMP-14 as a viable therapeutic in Dupuytren’s Disease
British Society For Surgery of the Hand
1/11/21 → 31/10/24
Project: Fellowship
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Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes
Cotton, S., McHugh, M. P., Dewar, R., Haas, J. G., Templeton, K. & The COVID-19 Genomics UK (COG-UK) Consortium, May 2023, In: Journal of Hospital Infection. 135, p. 28-36 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)7 Downloads (Pure) -
The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis
Pascall, D. J., Vink, E., Blacow, R., Bulteel, N., Campbell, A., Campbell, R., Clifford, S., Davis, C., Filipe, A. D. S., Sakka, N. E., Fjodorova, L., Forrest, R., Goldstein, E., Gunson, R., Haughney, J., Holden, M. T. G., Honour, P., Hughes, J., James, E., Lewis, T., & 17 others , 13 Apr 2023, In: PLoS One. 18, 4, e0284187.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)3 Downloads (Pure) -
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: A prospective observational cohort study
Kläser, K., Molteni, E., Graham, M., Canas, L. S., Österdahl, M. F., Antonelli, M., Chen, L., Deng, J., Murray, B., Kerfoot, E., Wolf, J., May, A., Fox, B., Capdevila, J., Modat, M., Hammers, A., COVID-19 Genomics U. K. (COG-UK) Consortium, Spector, T. D., Steves, C. J., Sudre, C. H., & 2 others , 28 Jun 2022, In: Scientific Reports. 12, 10904.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Citations (Scopus)11 Downloads (Pure) -
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission
Aggarwal, D., Page, A. J., Schaefer, U., Savva, G. M., Myers, R., Volz, E., Ellaby, N., Platt, S., Groves, N., Gallagher, E., Tumelty, N. M., Le Viet, T., Hughes, G. J., Chen, C., Turner, C., Logan, S., Harrison, A., COVID-19 Genomics UK (COG-UK) Consortium, Peacock, S. J., Chand, M., & 1 others , 23 Feb 2022, In: Nature Communications. 13, 1012.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)16 Downloads (Pure) -
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
Aggarwal, D., Warne, B., Jahun, A. S., Hamilton, W. L., Fieldman, T., du Plessis, L., Hill, V., Blane, B., Watkins, E., Wright, E., Hall, G., Ludden, C., Myers, R., Hosmillo, M., Chaudhry, Y., Pinckert, M. L., Georgana, I., Izuagbe, R., Leek, D., Nsonwu, O., & 23 others , 8 Feb 2022, In: Nature Communications. 13, 751.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)10 Downloads (Pure)
Prizes
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Chancellor's Award for Outstanding Achievement
Davidson, Rosemary (Recipient), 2021
Prize: Prize (including medals and awards)
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Fahrenheit Placement Prize for Excellence
Davidson, Rosemary (Recipient), 2004
Prize: Prize (including medals and awards)
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Food Chemistry Advances (Journal)
Rosemary Davidson (Editorial board member)
2022Activity: Editorial work › Publication editorial role
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Chinese Society for Anatomical Sciences
Rosemary Davidson (Speaker)
9 Nov 2021Activity: Participating in or organising an event › Participation in conference
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Frontier of Life Science and Technology
Rosemary Davidson (Speaker)
7 Nov 2021Activity: Participating in or organising an event › Participation in conference
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Norwich Medical School MB BS Interview Panel
Rosemary Davidson (Member)
Sept 2021 → …Activity: Other activity types › Other
Press/Media
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Making an impact: how local researchers are changing the world
14/07/21
1 item of Media coverage
Press/Media: Media Coverage or Contribution
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Meet the scientist specialising in Covid testing technology
24/04/21
1 item of Media coverage
Press/Media: Media Coverage or Contribution
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UEA makes new coronavirus test for hundreds more patients a day
23/04/20
1 item of Media coverage
Press/Media: Media Coverage or Contribution
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Broccoli: Researchers say it slows arthritis
28/08/13
1 item of Media coverage
Press/Media: Media Coverage or Contribution
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Broccoli slows arthritis, researchers think
23/08/13
1 item of Media coverage
Press/Media: Media Coverage or Contribution