Research output per year
Research output per year
- 33 results
Search results
-
2004
Functional up-regulation of KCNA gene family expression in murine mesenteric resistance artery smooth muscle
Fountain, S. J., Cheong, A., Flemming, R., Mair, L., Sivaprasadarao, A. & Beech, D. J., 2004, In: The Journal of Physiology. 556, 1, p. 29-42 14 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
Human TRPC5 channel activated by a multiplicity of signals in a single cell
Zeng, F., Xu, S-Z., Jackson, P. K., McHugh, D., Kumar, B., Fountain, S. J. & Beech, D. R., 14 Jul 2004, In: The Journal of Physiology. 559, p. 739-750 12 p.Research output: Contribution to journal › Article › peer-review
112 Citations (Scopus) -
2006
A C-terminal Lysine That Controls Human P2X4 Receptor Desensitization
Fountain, S. J. & North, A. R., 13 Mar 2006, In: The Journal of Biological Chemistry. 281, p. 15044-15049 6 p.Research output: Contribution to journal › Article › peer-review
62 Citations (Scopus) -
2007
An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum
Fountain, S. J., Parkinson, K., Young, M. T., Cao, L., Thompson, C. R. L. & North, A. R., 12 Jul 2007, In: Nature. 448, p. 200-203 4 p.Research output: Contribution to journal › Article › peer-review
114 Citations (Scopus) -
Kv1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress
Fountain, S. J., Cheong, A., Li, J., Dondas, N. Y., Zeng, F., Wood, I. C. & Beech, D. J., Nov 2007, In: AJP - Heart and Circulatory Physiology. 293, 5, p. 2719-2725 7 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Thr339-to-Serine Substitution in Rat P2X2 Receptor Second Transmembrane Domain Causes Constitutive Opening and Indicates a Gating Role for Lys308
Cao, L., Young, M. T., Broomhead, H. E., Fountain, S. J. & North, A. R., 21 Nov 2007, In: The Journal of Neuroscience. 27, 47, p. 12916-12923 8 p.Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus) -
2008
Molecular Shape, Architecture, and Size of P2X4 Receptors Determined Using Fluorescence Resonance Energy Transfer and Electron Microscopy
Young, M. T., Fisher, J. A., Fountain, S. J., Ford, R. C., North, R. A. & Khakh, B. S., 19 Sep 2008, In: The Journal of Biological Chemistry. 283, 38, p. 26241-26251 11 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Permeation Properties of a P2X Receptor in the Green Algae Ostreococcus tauri
Fountain, S. J., Cao, L., Young, M. T. & North, R. A., 30 May 2008, In: The Journal of Biological Chemistry. 283, p. 15122-15126 5 p.Research output: Contribution to journal › Article › peer-review
58 Citations (Scopus) -
2009
An evolutionary history of P2X receptor
Fountain, S. J. & Burnstock, G., 2009, In: Purinergic Signalling. 5, 3, p. 269-272 4 p.Research output: Contribution to journal › Article › peer-review
60 Citations (Scopus) -
Quantitative RT-PCR Methods for Investigation of Low Copy Potassium Channel Gene Expression in Native Murine Arteries
Cheong, A., Fountain, S. J. & Beech, D. J., 2009, In: Potassium Channels. 491, I, p. 19-33 15 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
2010
Neurotransmitter Receptor Homologues of Dictyostelium discoideum
Fountain, S. J., Jun 2010, In: Journal of Molecular Neuroscience. 41, 2, p. 263-266 4 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
2012
A Mechanism of Intracellular P2X Receptor Activation
Sivaramakrishnan, V. & Fountain, SJ., 2012, In: Journal of Biological Chemistry. 287, 34, p. 28315-28326 12 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes
Sivaramakrishnan, V., Bidula, S., Campwala, H., Katikaneni, D. & Fountain, S. J., 1 Oct 2012, In: Journal of Cell Science. 125, 19, p. 4567-4575Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
Fluvastatin suppresses native and recombinant human P2X4 receptor function
Li, J. & Fountain, SJ., Jun 2012, In: Purinergic Signalling. 8, 2, p. 311-316 6 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2013
Constitutive and agonist stimulated ATP secretion in leukocytes
Campwala, H. & Fountain, S. J., 13 May 2013, In: Communicative and Integrative Biology. 6, 3, p. e23631Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Intracellular P2X receptors as novel calcium release channels and modulators of osmoregulation in Dictyostelium: A comparison of two common laboratory strains
Sivaramakrishnan, V. & Fountain, SJ., 2013, In: Channels. 7, 1, p. 43-46 3 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
Primitive ATP-activated P2X receptors: discovery, function and pharmacology
Fountain, S. J., 6 Dec 2013, In: Frontiers in Cellular Neuroscience. 7, 247.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
2014
P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells
Campwala, H., Sexton, D. W., Crossman, D. C. & Fountain, S. J., 15 Nov 2014, In: Journal of Cell Science. 127, 22, p. 4964-4973 10 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
2015
Evidence for extracellular ATP as a stress signal in a single-celled organism
Fountain, S. & Sivaramakrishnan, V., 2015, In: Eukaryotic Cell. 14, 8, p. 775-782 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)5 Downloads (Pure) -
2017
Influence of ER leak on resting cytoplasmic Ca2+ and receptormediated Ca2+ signalling in human macrophage
Layhadi, J. A. & Fountain, S. J., 3 Jun 2017, In: Biochemical and Biophysical Research Communications. 487, 3, p. 633–639 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)10 Downloads (Pure) -
P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages
Layhadi, J. & Fountain, S., 27 Oct 2017, In: International Journal of Molecular Sciences. 18, 11, 2261.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)7 Downloads (Pure) -
P2X4 receptor function in the nervous system and current breakthroughs in pharmacology
Stokes, L., Layhadi, J. A., Bibic, L., Dhuna, K. & Fountain, S. J., 23 May 2017, In: Frontiers in Pharmacology. 8, 291.Research output: Contribution to journal › Article › peer-review
Open AccessFile65 Citations (Scopus)14 Downloads (Pure) -
2018
ATP Evokes Ca2+ Responses and CXCL5 Secretion via P2X4 Receptor Activation in Human Monocyte-Derived Macrophages
Layhadi, J. A., Turner, J., Crossman, D. & Fountain, S. J., 1 Feb 2018, In: Journal of Immunology. 200, 3, p. 1159-1168Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus) -
Constitutive P2Y2 receptor activity regulates basal lipolysis in human adipocytes
Ali, S. B., Turner, J. J. O. & Fountain, S. J., 19 Nov 2018, In: Journal of Cell Science. 131, 22, jcs221994.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)7 Downloads (Pure) -
P2Y12 receptor modulation of ADP‐evoked intracellular Ca2+ signalling in THP‐1 human monocytic cells
Micklewright, J. J., Layhadi, J. A. & Fountain, S. J., Jun 2018, In: British Journal of Pharmacology. 175, 12, p. 2483-2491Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)8 Downloads (Pure) -
P2Y2 and P2Y6 receptor activation elicits intracellular calcium responses in human adipose-derived mesenchymal stromal cells
Ali, S., Turner, J. & Fountain, S. J., Dec 2018, In: Purinergic Signalling. 14, 4, p. 371–384Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)15 Downloads (Pure) -
2019
Action of MK‐7264 (Gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation
Richards, D., Gever, J. R., Ford, A. P. & Fountain, S., Jul 2019, In: British Journal of Pharmacology. 176, 13, p. 2279-2291 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)54 Downloads (Pure) -
ATP-evoked intracellular Ca2+ responses in M-CSF differentiated human monocyte-derived macrophage are mediated by P2X4 and P2Y11 receptor activation
Layhadi, J. A. & Fountain, S. J., 15 Oct 2019, In: International Journal of Molecular Sciences. 20, 20, 5113.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)11 Downloads (Pure) -
Inhibitors of diacylglycerol metabolism suppress CCR2 receptor signalling in human monocytes
Day, P., Burrows, L., Richards, D. & Fountain, S. J., Aug 2019, In: British Journal of Pharmacology. 176, 15, p. 2736-2749Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)14 Downloads (Pure) -
2020
SUN1/2 are essential for RhoA/ROCK-regulated actomyosin activity in isolated vascular smooth muscle cells
Porter, S., Minaisah, R. M., Ahmed, S., Ali, S., Norton, R., Zhang, Q., Ferraro, E., Molenaar, C., Holt, M., Cox, S., Fountain, S., Shanahan, C. & Warren, D., 6 Jan 2020, In: Cells. 9, 1, 17 p., 132.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)37 Downloads (Pure) -
2021
Neuropeptide Y facilitates P2X1 receptor-dependent vasoconstriction via Y1 receptor activation in small mesenteric arteries during sympathetic neurogenic responses
Gonzalez-Montelongo, M. & Fountain, S. J., Feb 2021, In: Vascular Pharmacology. 136, 106810.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)2 Downloads (Pure) -
Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition
Nadzirin, I. B., Fortuny‐Gomez, A., Ngum, N., Richards, D., Ali, S., Searcey, M. & Fountain, S. J., Dec 2021, In: British Journal of Pharmacology. 178, 24, p. 4859-4872 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
2022
Structural basis of the negative allosteric modulation of 5-BDBD at human P2X4 receptors
Bidula, S., Nadzirin, I. B., Cominetti, M., Hickey, H., Cullum, S. A., Searcey, M., Schmid, R. & Fountain, S. J., 1 Jan 2022, In: Molecular Pharmacology. 101, 1, p. 33-44 12 p.Research output: Contribution to journal › Article › peer-review