Shannon Weldon

Shannon Weldon


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Personal profile


I graduated top of my class with a First Class Bachelor of Arts degree in Comparative Biology from Trinity College Dublin. For my final year I wrote my undergraduate thesis, titled "Molecular cuckoo clocks – a genetic investigation of members of the cuckoo family (Cuculidae) in SE Sulawesi".

I am currenty a PhD Student here at UEA where my main area of research is in assessing the complexity of embryonic somites with single cell genomics, using the chick as my model organism. 

Key Research Interests and Expertise

A fascinating question in biology asks how multicellular organisms arise from a single cell: the fertilized egg. During embryogenesis, naïve and still plastic progenitor cells communicate with each other, first to form different layers and to organize the main body axes, and later to build specialized organs with highly differentiated cell types and functions. The cells in an embryo coordinate these complex events by activating gene expression programmes, often in response to extrinsic signals. The control of cell differentiation is important throughout the life of an organism, for example to repair tissue after injury or for growth and remodeling using tissue resident stem cells, which activate cellular differentiation programmes similar to those used in the embryo. However, many details of how cells progressively differentiate - at the right time and in the right place - are still poorly understood. This will be addressed here in developing somites, paired segments along the axis of vertebrate embryos, which generate much of the musculoskeletal system from an initially homogenous population of cells. My project will use advanced (low input) sequencing techniques to determine molecular profiles of progenitor cells present in early somites. By looking at different stages of somite differentiation we will characterize cellular intermediates and transition states as more specialised cell types arise.

Education/Academic qualification

Bachelor of Arts, Trinity College Dublin

1 Sep 201431 May 2018

Award Date: 2 Nov 2018