Projects per year
Personal profile
Biography
Upon completing postgraduate work at the Medical Research Council’s Clinical Research Centre, Harrow “emigrated” to the USA to take up a postdoctoral position at New York University School of Medicine. After ~14 months left New York to take up a Howard Hughes Fellowship position in the Immunobiology Group at Yale University with Profs Kim Bottomly and Charlie Janeway. While at Yale an interest in gamma-delta (γδ) T cells was acquired working closely with Adrian Hayday on molecular genetics and then with Prof Peter Doherty to establish their role in infectious disease. Left Yale after five years to take up a faculty position at the University of Pennsylvania in Philadelphia. During this time an interest in mucosal and GI-tract immunology, developed performing studies in germfree mice with John Cebra that helped establish the role of gut microbes in the aetiology of inflammatory bowel disease (IBD). After 15 years in the USA, returned to the UK to take up the Chair in Molecular Immunology at the University of Leeds. At Leeds the focus of the research was on γδ T cell biology and the role these cells play in mucosal immunity. In addition a new programme on Bacteroides genetics was undertaken leading to the development of a Bacteroides drug delivery platform that is being used for developing new interventions for IBD and for mucosal vaccination. Left Leeds in 2008 to take up the position of Professor of Mucosal Immunology at UEA-MED and leader of the Gut Biology Research Programme, which eventually became part of the Gut Health and Food Safety (GHFS) Programme. The GHFS programme comprises 13 research groups led by individual group leaders that cover a broad area of gut biology including epithelial cell physiology and epigenetics, mucus and glycobiology, mucosal immunology, commensal microbiology, foodborne bacterial pathogens, and mathematical modelling and bioinformatics. The total number of scientists working in the programme is currently about 60. Within this programme, much of the work undertaken in the Carding research group builds upon that carried out in the USA and latterly in the UK with a major focus on understanding the mechanisms of intestinal microbial tolerance and the role that microbe-host cross talk plays in establishing and maintaining gut health and in gut diseases such as IBD.
Career
PhD MRC-Clinical Research Centre, Harrow UK 1985
Visiting Instructor, New York Univ. Sch. Medicine, New York, USA, 1985-1986
Postdoctoral Associate, Yale Univ. Sch. Med, New Haven, USA, 1986-1989
Howard Hughes Fellow, Yale Univ. Sch. Medicine, New Haven, USA, 1989-1991
Assistant/Associate Professor, Univ. Pennsylvania, Phildelphia, USA, 1991-1999
Professor Molecular Immunology, Leeds Univ., Leeds UK, 1999-2008
Professor Mucosal Immunology, Norwich Medical School, UEA, 2008-
Head, Gut Health and Food Safety Research Programme, Institute of Food Research, 2008
Key Research Interests
Much of the work undertaken in the Carding research group based at IFR focuses on understanding the mechanisms of intestinal microbial tolerance and the role that microbe-host cross talk plays in establishing and maintaining gut health and in gut disease. Current research interests are, defining the link between the mucosal immune system, dendritic cells (DC) and lipid metabolism using a novel experimental model of obesity, the role autophagy plays in intestinal epithelial cell homeostasis, barrier function and mucosal immune responses to commensal and pathogenic microbes, the nature of mucosal immune cell (iIEL)-microbiota interactions in establishing and maintaining a healthy intestinal microbiome while mounting immediate response to food-borne pathogens, regulation of epithelial tight junctions and the maintenance of intestinal barrier function, interkingdom macromolecule exchange in microbe-host crosstalk and the establishment of mutualism in the GI-tract, development of novel strategies to treat and prevent chronic intestinal inflammation and IBD using SMART bacteria and novel foods, immune tolerance and implant rejection and, immunosenescence and diet.
Research Keywords
Gut biology and gastroenterology
Intestinal epithelial cells
Intestinal microbiology
Mucosal immunology
Postgraduate Research Student Supervision
Gut biology
Gut microbiology
Mucosal innate immunity
Inflammatory bowel disease
Plant and microbe based therapies for gut disease
Highlighted Publications
- Baumgart, DB and SR. Carding. 2007. Inflammatory bowel disease: Aetiology and Immunopathogenesis. The Lancet. 369:1627-1638 ·
- Cruickshank, SM, ML. Deschoolmeester, M. Svensson, A. Bazakou, G. Howell, L. Logunova, MC. Little, N. English, RK. Grencis, KJ. Else and SR. Carding. 2009. Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection. J. Immunol. 182:3055-3062 ·
- Hamady, ZR, MD. Farrar, TR. Whitehead, KT. Holland, JPA. Lodge and SR. Carding. 2010. Xylan regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Gut. 59:461-469 ·
- Mizushima, N, TS Stappenbeck, JD Rioux, A Mizoguchi, T Saitoh, A Huett, A Darfeuille Michaud, SR Carding, T Wileman, S Akira, M Parkes, RJ Xavier. 2010 Crohns disease: A current perspective on genetics, autophagy and immunity. Autophagy. 7:355-374 ·
- Hamady Z. R., Scott N., Farrar M. D., Dilger P. G., Thorpe R., Lodge J. P. A., Holland K. T., Whitehead T., Carding S. R. (2011). Treatment of colitis with a commensal gut bacterium engineered to secrete human TGF-#f0621 under the control of dietary xylan. Inflammatory Bowel Disease 17 (9) 1925-1935 ·
- Weight C. M., Carding S. R. (2012). The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium. Annals of the New York Academy of Sciences 1258 (1) 135-142
- Pin C., Watson A., Carding S. (2012). Modelling the spatio-temporal cell dynamics reveals novel insights on cell differentiation and proliferation in the small intestinal crypt. PLoS ONE 7 (5) e37115. · Wegmann, U, N. Horn, SR. Carding 2013. Defining the Bacteriodes ribosomal binding site. Appl. Env. Microbiol. 79:1980-89
Key Responsibilities
Leader, Gut Health and Food Safety Research Programme at the Institute of Food Research Chair and/or member of more than 10 committees at IFR involved in overseeing or managing research-related activities.
Professional/External Activities and Indicators of Esteem
Activity / Indicator of Esteem | Date/ Year | Additional Info |
RCUK Grant Review and Advisory Panels | 2000- | |
Grant Review for International Funding Bodies | 2008- | |
Advisory Boards for Biomedical Charities and Industry | 2000- | |
Invited speaker at national and international conferences | 1990- | |
Reviewer for international journals | 1986- |
Enterprise and Engagement Activities
Activity / Indicator of Esteem | Date / Year | Additional Info |
Founder/Chief Executive, Ovatus Ltd. Spin out company | 2009-2012 | |
UK and international Patents for Ovatus Ltd | 2009-2013 |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 21 Finished
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The role of LC3-associated phagocytosis during viral infection
Wileman, T., Carding, S., Mayer, U. & Powell, P.
Biotechnology and Biological Sciences Research Council
9/04/18 → 8/04/21
Project: Research
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Identifying novel microorganisms to promote human health
Lehtovirta-Morley, L., Carding, S., Carding, S. & Murrell, C.
1/03/18 → 31/12/18
Project: Research
-
B lympocyte depletion in Chronic Fatigue Syndrome
Macgregor, A., Carding, S. & Wileman, T.
1/06/17 → 31/05/18
Project: Research
-
Using engineered gut bacteria-derived microvesicles for plague vaccines.
1/05/17 → 30/04/18
Project: Research
-
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An in vitro multi-organ microphysiological system (MPS) to investigate the gut-to-brain translocation of neurotoxins
Jones, E. J., Skinner, B. M., Parker, A., Baldwin, L. R., Greenman, J., Carding, S. R. & Funnell, S. G. P., Sep 2024, In: Biomicrofluidics. 18, 5, 054105.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Assessing functional capacity in myalgic encephalopathy/chronic fatigue syndrome: A patient-informed questionnaire
Sommerfelt, K., Schei, T., Seton, K. A. & Carding, S. R., 14 Jun 2024, In: Journal of Clinical Medicine. 13, 12, 3486.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Assessing In Vivo Bacterial Extracellular Vesicle (BEV) Biodistribution Using Fluorescent Lipophilic Membrane Stains
Jones, E. J., Stentz, R., Parker, A. & Carding, S. R., 15 Aug 2024, Bacterial Extracellular Vesicles: Methods and Protocols. Humana Press Inc, p. 239-251 13 p. (Methods in Molecular Biology; vol. 2843).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Differential temporal release and lipoprotein loading in B. thetaiotaomicron bacterial extracellular vesicles
Juodeikis, R., Martins, C., Saalbach, G., Richardson, J., Koev, T., Baker, D. J., Defernez, M., Warren, M. & Carding, S. R., Jan 2024, In: Journal of Extracellular Vesicles. 13, 1, 12406.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)22 Downloads (Pure) -
Nanopore and Illumina sequencing reveal different viral populations from human gut samples
Cook, R., Telatin, A., Hsieh, S. Y., Newberry, F., Tariq, M. A., Baker, D. J., Carding, S. R. & Adriaenssens, E. M., 29 Apr 2024, In: Microbial Genomics. 10, 4, 001236.Research output: Contribution to journal › Article › peer-review
Open AccessFile