Projects per year
Personal profile
Biography
During my PhD in the School of Medicine (UEA) with Dr Silke Schelenz, I focused on understanding how soluble immune receptors found in the lungs and bloodstream could recognise and protect against pathogenic fungi. Following my PhD, I made the move north to sunny Aberdeen and under the guidance of Prof. Gordon Brown helped characterise the first receptor for melanin. Here, we found that this receptor was critical for antifungal immunity in humans and mice. I made a return to UEA in 2016 where I have focused on characterising novel allosteric modulators of purinergic receptors and understanding their biological roles (Dr. Leanne Stokes and Prof. Samuel Fountain). I have since recently been appointed as Lecturer in Pharmacology in the School of Pharmacy where I will endeavour to understand how the human body detects and responds to invasion by fungal pathogens, identify novel drug targets to overcome antifungal resistance, and explore how to prevent inflammation-driven diseases.
My experience is widely varied and encompasses host-microbe interactions, microbial genomics, nucleic acids biology, biophysics, drug discovery, cell death, cardiovascular biology, immune cell receptors, in-silico modelling, bioinformatics, and chemical biology.
Career
- Lecturer of Pharmacology, University of East Anglia (2022 - present)
- Senior Research Associate (BHF), University of East Anglia (2020 - 2022)
- Senior Research Associate (BBSRC), University of East Anglia (2016 - 2019)
- Research Associate (Wellcome Trust), University of Aberdeen (2014 - 2016)
- PhD in Biomedical Sciences, University of East Anglia (2011 - 2015)
- BSc (Hons) Genetics and Molecular Biology, University of East Anglia (2008 - 2011)
Collaborations and top research areas from the last five years
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Spectroscopic and synthetic facilities for supramolecular and macromolecular systems
Le Brun, N., Beekman, A., Bidula, S., Bradley, J., Butt, J., Cammidge, A., Cheesman, M., Crack, J., Delso, I., Ganesan, A., Gates, A., Hamilton, C., Sachdeva, A., Searcey, M. & Wallace, M.
Engineering and Physical Sciences Research Council
1/01/25 → 30/06/26
Project: Research
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Four-stranded fungal fatality: Unveiling G-quadruplexes as future antifungal targets
Bidula, S. & Macdonald, C.
Biotechnology and Biological Sciences Research Council
3/06/24 → 2/06/27
Project: Research
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Exploring the contribution of secondary metabolites to fungal immune evasion
1/12/23 → 31/05/25
Project: Research
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Discovery of novel secondary metabolites from marine organisms
Royal Embassy of Saudi Arabia Cultural Bureau, London
1/10/23 → 30/09/25
Project: Training
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Targeting G-quadruplexes to modulate secondary metabolite production in Aspergillus spp.
1/09/23 → 31/08/25
Project: Research
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A microtubule stability switch alters isolated vascular smooth muscle Ca2+ flux in response to matrix rigidity
Johnson, R. T., Wostear, F., Solanki, R., Steward, O., Bradford, A., Morris, C., Bidula, S. & Warren, D. T., Nov 2024, In: Journal of Cell Science. 137, 21, jcs262310.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Immunology of Fungal Infections
Middleton, G. & Bidula, S., 2024, Reference Module in Life Sciences. ElsevierResearch output: Chapter in Book/Report/Conference proceeding › Chapter
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Piezo1-mediated regulation of smooth muscle cell volume in response to enhanced extracellular matrix rigidity
Johnson, R. T., Solanki, R., Wostear, F., Ahmed, S., Taylor, J. C. K., Rees, J., Abel, G., McColl, J., Jørgensen, H. F., Morris, C. J., Bidula, S. & Warren, D. T., Jun 2024, In: British Journal of Pharmacology. 181, 11, p. 1576-1595 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Purinergic P2X Receptors as Therapeutic Targets
Stokes, L., Bidula, S. & Sluyter, R., 25 Apr 2024, Ion Channels as Targets in Drug Discovery. Springer, p. 439-460 22 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
Bidula, S., Piyasirananda, W., Bielecka, H., Bibič, L., Beekman, A. & Stokes, L., 22 Oct 2024, (E-pub ahead of print) In: Purinergic Signalling.Research output: Contribution to journal › Article › peer-review
Open Access
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Virulence (Journal)
Stefan Bidula (Associate Editor)
18 May 2022 → …Activity: Editorial work › Publication editorial role
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Frontiers in Aging (Journal)
Stefan Bidula (Guest editor)
2022 → …Activity: Editorial work › Publication editorial role
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Frontiers in Immunology (Journal)
Stefan Bidula (Guest editor)
13 Jul 2021 → …Activity: Editorial work › Publication editorial role
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Critical Reviews in Microbiology (Journal)
Stefan Bidula (Associate Editor)
30 Nov 2020 → …Activity: Editorial work › Publication editorial role
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Freelance Manuscript Copyeditor
Stefan Bidula (Contributor)
2020 → …Activity: Other activity types › Other