Stefan Bidula

Search results

• 2025

  The cytochalasans: Potent fungal natural products with application from bench to bedside

  Tammam, M. A., Pereira, F., Skellam, E., Bidula, S., Ganesan, A. & El-Demerdash, A., 24 Feb 2025, (E-pub ahead of print) In: Natural Product Reports.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
• 2024

  A microtubule stability switch alters isolated vascular smooth muscle Ca²⁺ flux in response to matrix rigidity

  Johnson, R. T., Wostear, F., Solanki, R., Steward, O., Bradford, A., Morris, C., Bidula, S. & Warren, D. T., Nov 2024, In: Journal of Cell Science. 137, 21, jcs262310.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  2 Downloads (Pure)

• Immunology of Fungal Infections

  Middleton, G. & Bidula, S., 2024, Reference Module in Life Sciences. Elsevier

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Piezo1-mediated regulation of smooth muscle cell volume in response to enhanced extracellular matrix rigidity

  Johnson, R. T., Solanki, R., Wostear, F., Ahmed, S., Taylor, J. C. K., Rees, J., Abel, G., McColl, J., Jørgensen, H. F., Morris, C. J., Bidula, S. & Warren, D. T., Jun 2024, In: British Journal of Pharmacology. 181, 11, p. 1576-1595 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  4 Citations (Scopus)

  12 Downloads (Pure)

• Purinergic P2X Receptors as Therapeutic Targets

  Stokes, L., Bidula, S. & Sluyter, R., 25 Apr 2024, Ion Channels as Targets in Drug Discovery. Springer, p. 439-460 22 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7

  Bidula, S., Piyasirananda, W., Bielecka, H., Bibič, L., Beekman, A. & Stokes, L., 22 Oct 2024, (E-pub ahead of print) In: Purinergic Signalling.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  Genomic analysis of non-B nucleic acids structures in SARS-CoV-2: Potential key roles for these structures in mutability, translation, and replication?

  Bidula, S. & Brázda, V., 6 Jan 2023, In: Genes. 14, 1, 157.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  3 Citations (Scopus)

  11 Downloads (Pure)

• Variability of inverted repeats in all available genomes of bacteria

  Porubiaková, O., Havlík, J., Indu, Šedý, M., Přepechalová, V., Bartas, M., Bidula, S., Šťastný, J., Fojta, M. & Brázda, V., 17 Aug 2023, In: Microbiology Spectrum. 11, 4, e01648-23.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  1 Citation (Scopus)

  7 Downloads (Pure)
• 2022

  Conservation and over-representation of G-quadruplex sequences in regulatory regions of mitochondrial DNA across distinct taxonomic sub-groups

  Bohálová, N., Dobrovolná, M., Brázda, V. & Bidula, S., Mar 2022, In: Biochimie. 194, p. 28-34 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  10 Citations (Scopus)

  11 Downloads (Pure)

• Inverted repeats in the monkeypox virus genome are hot spots for mutation

  Dobrovolná, M., Brázda, V., Warner, E. F. & Bidula, S., 3 Dec 2022, In: Journal of Medical Virology. 95, 1, e28322.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  15 Citations (Scopus)

  9 Downloads (Pure)

• Structural basis of the negative allosteric modulation of 5-BDBD at human P2X4 receptors

  Bidula, S., Nadzirin, I. B., Cominetti, M., Hickey, H., Cullum, S. A., Searcey, M., Schmid, R. & Fountain, S. J., 1 Jan 2022, In: Molecular Pharmacology. 101, 1, p. 33-44 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  14 Citations (Scopus)

  22 Downloads (Pure)
• 2021

  Analysis of putative G-quadruplex forming sequences in inflammatory mediators and their potential as targets for treating inflammatory disorders

  Bidula, S., Jun 2021, In: Cytokine. 142, 155493.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  8 Citations (Scopus)

  11 Downloads (Pure)

• Analysis of putative quadruplex-forming sequences in fungal genomes: Novel antifungal targets?

  Warner, E. F., Bohálová, N., Brázda, V., Waller, Z. A. E. & Bidula, S., May 2021, In: Microbial Genomics. 7, 5, 000570.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  7 Citations (SciVal)

  29 Downloads (Pure)

• Bis(N-picolinamido)cobalt(II) complexes display antifungal activity toward Candida albicans and Aspergillus fumigatus

  Ghandhi, L. H. D., Bidula, S., Pask, C. M., Lord, R. M. & McGowan, P. C., 15 Oct 2021, In: ChemMedChem. 16, 20, p. 3210-3221 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  3 Citations (SciVal)

  43 Downloads (Pure)

• Dioscin-related glycosides as positive allosteric modulators of P2X7 receptors

  Stokes, L., Bielecka, H., Felgate, M., Beekman, A., Ngameni, B., Chi, G. F., Stephenson, R. & Bidula, S., Dec 2021, In: British Journal of Pharmacology. 178, 24, p. 4947 1 p.

  Research output: Contribution to journal › Abstract › peer-review

• Insights into the structure-activity relationship of glycosides as positive allosteric modulators acting on P2X7 receptors

  Piyasirananda, W., Beekman, A., Ganesan, A., Bidula, S. & Stokes, L., 1 Feb 2021, In: Molecular Pharmacology. 99, 2, p. 163-174 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  12 Citations (SciVal)

  27 Downloads (Pure)
• 2020

  Revisiting the past to enhance the future: Traditional medicinal plant extracts in the discovery of novel drug lead to target P2X7

  Bidula, S., Bibic, L., Moulton, A., Zhang, J. & Stokes, L., Jun 2020, In: British Journal of Pharmacology. 177, 11, p. 2628-2629 2 p.

  Research output: Contribution to journal › Abstract › peer-review

• To inhibit or enhance? Is there a benefit to positive allosteric modulation of P2X receptors?

  Stokes, L., Bidula, S., Bibič, L. & Allum, E., 12 May 2020, In: Frontiers in Pharmacology. 11, 627.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  25 Citations (Scopus)

  29 Downloads (Pure)
• 2019

  Ficolins and the recognition of pathogenic microorganisms: An overview of the innate immune response and contribution of single nucleotide polymorphisms

  Bidula, S., Sexton, D. & Schelenz, S., 5 Feb 2019, In: Journal of Immunology Research. 2019, 3205072.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  35 Citations (SciVal)

  46 Downloads (Pure)

• Ginsenosides act as positive modulators of P2X₄ receptors

  Dhuna, K., Felgate, M., Bidula, S., Walpole, S., Bibic, L., Cromer, B., Angulo, J., Sanderson, J., Stebbing, M. & Stokes, L., Jan 2019, In: Molecular Pharmacology. 95, 2, p. 210-221 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  23 Citations (SciVal)

  21 Downloads (Pure)

• Herbaceous homicide: The Panax ginseng metabolite compound K accelerates caspase-3/7 activation and enhances macrophage cell death in a P2X7-dependent manner

  Bidula, S., Dhuna, K., Helliwell, R., Stebbing, M. & Stokes, L., Aug 2019, In: British Journal of Pharmacology. 176, 16, p. 3028-3028 1 p.

  Research output: Contribution to journal › Abstract › peer-review

• Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7

  Bidula, S. M., Cromer, B. A., Walpole, S., Angulo, J. & Stokes, L., 1 Mar 2019, In: Scientific Reports. 9, 3231.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  18 Citations (SciVal)

  23 Downloads (Pure)

• Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages

  Bidula, S., Dhuna, K., Helliwell, R. & Stokes, L., 2019, In: Cell Death & Disease. 10, 882.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  32 Citations (SciVal)

  34 Downloads (Pure)
• 2018

  Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

  Stappers, M. H. T., Clark, A. E., Aimanianda, V., Bidula, S., Reid, D. M., Asamaphan, P., Hardison, S. E., Dambuza, I. M., Valsecchi, I., Kerscher, B., Plato, A., Wallace, C. A., Yuecel, R., Hebecker, B., da Glória Teixeira Sousa, M., Cunha, C., Liu, Y., Feizi, T., Brakhage, A. A., Kwon-Chung, K. J., & 13 othersGow, N. A. R., Zanda, M., Piras, M., Zanato, C., Jaeger, M., Netea, M. G., van de Veerdonk, F. L., Lacerda, J. F., Campos, A., Carvalho, A., Willment, J. A., Latgé, J-P. & Brown, G. D., 15 Mar 2018, In: Nature. 555, p. 382–386

  Research output: Contribution to journal › Article › peer-review
  157 Citations (SciVal)
• 2016

  A sweet response to a sour situation: The role of soluble pattern recognition receptors in the innate immune response to invasive Aspergillus fumigatus infections

  Bidula, S. & Schelenz, S., 14 Jul 2016, In: PLoS Pathogens. 12, 7, e1005637.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  12 Citations (SciVal)

  6 Downloads (Pure)

• Immunology of Fungal Infections

  Bidula, S. & Brown, G. D., 27 Apr 2016, Encyclopedia of Immunobiology. Ratcliffe, M. J. H. (ed.). Elsevier, Vol. 4. p. 75-82 8 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  1 Citation (Scopus)

• Serum opsonin ficolin-A enhances host–fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge

  Bidula, S., Sexton, D. W. & Schelenz, S., Apr 2016, In: Medical Microbiology and Immunology. 205, 2, p. 133-142 10 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (SciVal)
• 2015

  H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses

  Bidula, S., Sexton, D. W., Yates, M., Abdolrasouli, A., Shah, A., Wallis, R., Reed, A., Armstrong-James, D. & Schelenz, S., Oct 2015, In: Immunology. 146, 2, p. 281-291 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  37 Citations (SciVal)

  7 Downloads (Pure)

• The serum opsonin L-ficolin is detected in lungs of human transplant recipients following fungal infections and modulates inflammation and killing of Aspergillus fumigatus

  Bidula, S., Sexton, D. W., Abdolrasouli, A., Shah, A., Reed, A., Armstrong-James, D. & Schelenz, S., 15 Jul 2015, In: Journal of Infectious Diseases. 212, 2, p. 234-246 13 p.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (SciVal)
• 2013

  Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans

  Schelenz, S., Kirchhof, N., Bidula, S., Wallis, R. & Sexton, D. W., Apr 2013, In: Immunobiology. 218, 4, p. 477-83 7 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species

  Bidula, S., Kenawy, H., Ali, Y. M., Sexton, D., Schwaeble, W. J. & Schelenz, S., May 2013, In: Infection and Immunity. 81, 5, p. 1730-40 11 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)
• 2012

  Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes

  Sivaramakrishnan, V., Bidula, S., Campwala, H., Katikaneni, D. & Fountain, S. J., 1 Oct 2012, In: Journal of Cell Science. 125, 19, p. 4567-4575

  Research output: Contribution to journal › Article › peer-review
  41 Citations (SciVal)