Projects per year
- June 2011 – present. Lecturer in Cell Signalling and Angiogenesis, University of East Anglia, School of Biological Sciences, Norwich Research Park, Norwich, UK.
- 2000 – May 2011. Postdoctoral Fellow, Cancer Research UK, Cell Adhesion and Disease Lab, Centre of Tumour Biology, QMUL, Bart’s Institute of Cancer, London, UK.
- 1993 - 2000. Postdoctoral Fellow, Massachusetts Institute of Technology, Boston, USA. Under the tutelage of Dr Richard O Hynes.
- 1987 - 1993. Graduate Student, University of California, Santa Cruz, CA, USA. Under the tutelage of Dr Charles W Daniel.
- Member - British Association for Cancer Research
- Member - The British Society for Cell Biology
Key Research Interests
Angiogenesis is the process by which new blood vessels form from those that already exist. It is essential for normal processes such as wound healing. An imbalance in the process is associated with ageing and with a multitude of human diseases, including cancer. Our research is aimed at determining how different cells and molecules contribute to angiogenesis under both normal and pathological situations.
Much of my research to date has focused on the role of alphaVbeta3-integrin in angiogenesis. My work as a postdoctoral fellow in the laboratory of Professor Kairbaan Hodivala-Dilke contributed to the seminal findings that alphaVbeta3-integrin can act as a negative regulator of pathological angiogenesis (L.R. Reynolds et al., Nature Medicine 2002) and that low doses of alphaVbeta3-integrin inhibitors can up-regulate angiogenesis (A. Reynolds et al., Nature Medicine, 2009). Recently I showed also that alphaVbeta3-integrin regulates Neuropilin-1 (NRP1)’s function in angiogenesis (S.D. Robinson et al., Journal of Biological Chemistry, 2009).
Current Research Projects
My immediate goal, as I establish my own research group at UEA, is to determine whether we can exploit these latter findings to improve on existing angiogenic therapies.
I am using a number of endothelial- and pericyte-specific mouse knockouts in models of normal and abnormal angiogenesis to determine how alphaVbeta3-integrin and NRP1 expression regulates the angiogenic behavior of these two key cell-types. I also perform ex vivo and in vitro angiogenic assays on tissues and cells isolated from these knockout mice to determine the molecular mechanisms underlying any in vivo phenotypes uncovered.
My long-term goal is to discover novel therapeutic vascular targets that can be used to modulate angiogenesis during ageing and to control disease.
Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.
Postdocs and Fellows
I am always happy to discuss possibilities for postdoctoral work and collaborations. Possible funding routes include applying for fellowships, e.g. Royal Society, Breast Cancer Campaign, Cancer Research UK and others, or grant applications with you as a named postdoc.
Areas of Expertise
Key Research Interests
visit us at: www.therobinsonlab.co.uk
- 3C27 (Cancer Biology)
- M201 (Frontiers in Molecular Medicine)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Mrs Doggett Cancer Research Donation
1/02/18 → 31/01/25
Understanding how microbiota disturbances influence breast cancer metastatic niches.
Robinson, S. & Hall, L.
1/10/18 → 31/03/22
James Taylor's studentship
25/06/18 → 17/08/18
Understanding how antibiotic-induced microbiota disturbances affect breast cancer progression
18/06/18 → 12/08/18
A dissection of the interplay between neuropilin-1 and fibronectin binding intergrins in regulating endothelial migration and signalling.
Robinson, S. & Atkinson, S.
1/03/18 → 29/02/20
Endothelial VEGFR coreceptors neuropilin-1 and neuropilin-2 are essential for tumor angiogenesisBenwell, C. J., Johnson, R. T., Taylor, J. A. G. E., Price, C. A. & Robinson, S. D., Dec 2022, In: Cancer Research Communications. 2, 12, p. 1626–1640 15 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Downloads (Pure)
Using Immortalized Endothelial Cells to Study the Roles of Adhesion Molecules in VEGF-Induced SignalingTaylor, J. A. G. E., Benwell, C. J. & Robinson, S. D., 2022, VEGF Signaling: Methods and Protocols. Fiedler, L. R. & Pellet-Many, C. (eds.). Humana Press Inc, p. 133-141 9 p. (Methods in Molecular Biology; vol. 2475).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumor growthMcKee, A. M., Kirkup, B. M., Madgwick, M., Fowler, W. J., Price, C. A., Dreger, S. A., Ansorge, R., Makin, K. A., Caim, S., Le Gall, G., Paveley, J., Leclaire, C., Dalby, M. J., Alcon-Giner, C., Andrusaite, A., Feng, T-Y., Di Modica, M., Triulzi, T., Tagliabue, E., Milling, S. W. F. & 5 others, , 24 Sep 2021, In: iScience. 24, 9, 103012.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile18 Citations (Scopus)11 Downloads (Pure)
Bacterial strains augment cancer therapeuticsHall, L. & Robinson, S., Mar 2021, In: Nature Microbiology. 6, 3, p. 275-276 2 p.
Research output: Contribution to journal › Article › peer-review1 Citation (Scopus)
Endothelial neuropilin‐2 influences angiogenesis by regulating actin pattern development and α5‐integrin‐ p ‐FAK complex recruitment to assembling adhesion sitesBenwell, C. J., Taylor, J. A. G. E. & Robinson, S. D., 27 Aug 2021, In: The FASEB Journal. 35, 8, e21679.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)15 Downloads (Pure)