Stuart Rushworth

Search results

• 2012

  The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance

  Rushworth, S. A., Zaitseva, L., Murray, M. Y., Shah, N. M., Bowles, K. M. & MacEwan, D. J., 20 Dec 2012, In: Blood. 120, 26, p. 5188-5198 11 p.

  Research output: Contribution to journal › Article › peer-review
  234 Citations (Scopus)

• Understanding the role of miRNA in regulating NF-kB in blood cancer

  Rushworth, S. A., Murray, M. Y., Barrera, L. N., Heasman, S-A., Zaitseva, L. & MacEwan, D. J., 2012, In: American Journal of Cancer Research. 2, 1, p. 65-74 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  High basal nuclear levels of Nrf2 in acute myeloid leukemia reduces sensitivity to proteasome inhibitors

  Rushworth, S. A., Bowles, K. M. & MacEwan, D. J., 6 Jan 2011, In: Cancer Research. 71, 5, p. 1999-2009 11 p.

  Research output: Contribution to journal › Article › peer-review
  79 Citations (Scopus)

• Micro RNAs as a new therapeutic target towards leukaemia signalling

  Murray, M. Y., Rushworth, S. A. & MacEwan, D. J., Nov 2011, In: Cellular Signalling. 24, 2, p. 363-368 6 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1

  Heasman, S-A., Zaitseva, L., Bowles, K. M., Rushworth, S. A. & MacEwan, D. J., 11 Sep 2011, In: Oncotarget. 2, 9, p. 658-668 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  69 Citations (Scopus)

• Silencing FLIPL modifies TNF-induced apoptotic protein expression

  Zaitseva, L., Rushworth, S. A. & MacEwan, D. J., 1 Apr 2011, In: Cell Cycle. 10, 7, p. 1067-1072 6 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• The role of Nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells

  Rushworth, S. A. & MacEwan, D. J., 29 Mar 2011, In: Cancers. 3, 2, p. 1605-1621 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  46 Citations (Scopus)

• TNF mediates the sustained activation of Nrf2 in human monocytes

  Rushworth, S. A., Shah, S. & MacEwan, D. J., 15 Jul 2011, In: Journal of Immunology. 187, 2, p. 702-707 6 p.

  Research output: Contribution to journal › Article › peer-review
  64 Citations (Scopus)
• 2010

  FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism

  Rushworth, S. A., Zaitseva, L., Langa Marcano, S., Bowles, K. M. & MacEwan, D. J., 2010, In: Oncotarget. 1, 5, p. 359-366 8 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• LPS activation of the Nrf2 pathway in monocytes: role of PKC alpha

  White, H., Norton, R., Rushworth, S. A., Mc Carthy, E. & O'Connell, M. A., 2010, In: Immunology. 131, p. 146-147 2 p.

  Research output: Contribution to journal › Article › peer-review

• NF-kappaB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction

  Rushworth, S. A., Bowles, K. M., Raninga, P. & MacEwan, D. J., 1 Apr 2010, In: Cancer Research. 70, 7, p. 2973-2983 11 p.

  Research output: Contribution to journal › Article › peer-review
  57 Citations (Scopus)
• 2008

  Curcumin: potential for hepatic fibrosis therapy?

  O'Connell, M. & Rushworth, S., Feb 2008, In: British Journal of Pharmacology. 153, 3, p. 403-405 3 p.

  Research output: Contribution to journal › Article › peer-review
  66 Citations (Scopus)

• Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cδ and Nrf2

  Ogborne, R. M., Rushworth, S. & O'Connell, M., 27 Jun 2008, In: Biochemical and Biophysical Research Communications. 373, 4, p. 584-588 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  49 Citations (Scopus)

• HO-1 underlies resistance of AML cells to TNF-induced apoptosis

  Rushworth, S. A. & MacEwan, D. J., 1 Apr 2008, In: Blood. 111, 7, p. 3793-3801 9 p.

  Research output: Contribution to journal › Article › peer-review
  122 Citations (Scopus)

• Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes

  Rushworth, S. A., MacEwan, D. J. & O'Connell, M. A., 15 Nov 2008, In: Journal of Immunology. 181, 10, p. 6730-6737 8 p.

  Research output: Contribution to journal › Article › peer-review
  178 Citations (Scopus)

• TNF signaling gets FLIPped off : TNF-induced regulation of FLIP

  Rushworth, S. A., Taylor, A., Langa, S. & MacEwan, D. J., 2008, In: Cell Cycle. 7, 2, p. 194-199 6 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)
• 2005

  alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells

  Ogborne, R. M., Rushworth, S. A. & O'Connell, M. A., 2005, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 25, 10, p. 2100-2105 6 p.

  Research output: Contribution to journal › Article › peer-review
  111 Citations (Scopus)

• Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C

  Rushworth, S. A., Chen, X-L., Mackman, N., Ogborne, R. M. & O'Connell, M. A., 2005, In: Journal of Immunology. 175, 7, p. 4408-4415 8 p.

  Research output: Contribution to journal › Article › peer-review
  173 Citations (Scopus)
• 2004

  Haem oxygenase-1: a target for dietary antioxidants

  Ogborne, R. M., Rushworth, S. A., Charalambos, C. A. & O'Connell, M. A., 2004, In: Biochemical Society Transactions. 32, 6, p. 1003-1005 3 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)