Projects per year
Personal profile
Biography
Susan gained her BPharm from the University of Nottingham in 1991, qualified as a Pharmacist (RPSGB) in 1992 before receiving her PhD in Medicinal Chemistry, from the University of Bath in 1995 for a thesis entitled "Synthesis of Biodegradable Polymers for Delivery of Diagnostic Agents". She gained Post-Doctoral experience at the Institute of Macromolecular Chemistry, Prague (Royal Society European Fellowship), Johannes Gutenberg Universität, Mainz and the Inorganic Chemistry Laboratory, Oxford before taking up the Kinerton Lectureship of Organic Chemistry at Trinity College, Dublin. She joined the School in April 2003 as Lecturer of Medicinal Chemistry and was promoted to Senior lecturer in 2008.
She is currently the Chair of the University South East Asia Dialogue Group and was the Associate Dean for Admissions for the Faculty of Science from 2011 till 2016
PhD Positions
Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.
Selected Publications
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K. Buffet, I. Nierengarten, N. Galanos,E. Gillon, M. Holler,A. Imberty, S. E. Matthews, S. Vidal, S. P. Vincent,J.-F. Nierengarten |
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Pillar[5]arene-based glycoclusters: synthesis and multivalent binding to pathogenic bacterial lectins |
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Chem. Eur. J., 2016, 22, 2955-2963
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A. M. Boukerb, A. Rousset, N. Galanos, J.-B. Méar, M. Thepaut, T. Grandjean, E. Gillon, S. Cecioni, C. Abderrahmen, K. Faure, D. Redelberger, E. Kipnis, R. Dessein, S. Havet, B. Drablade, S. E. Matthews, S. de Bentzmann, B. Guéry, B. Cournoyer, A. Imberty, S. Vidal | |
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Anti-adhesive properties of glycoclusters against Pseudomonas aeruginosa lung infection | |
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J. Med. Chem., 2014, 57, 10275-10289
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Y. Brissonnet, C. Ortiz-Mellet, S. Morandat, D. Deniaud, S. E. Matthews, S. Vidal, K. El Kirat S. G. Gouin | |
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Topological effects and binding modes operating with multivalent iminosugar-based glycoclusters and glycosidases | |
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J. Am. Chem. Soc. 2013, 135, 18427-18435
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S. Cecioni, J.-P. Praly, S. E. Matthews M. Wimmerová, A. Imberty, S. Vidal | |
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Rational design and synthesis of optimized glycoclusters for multivalent lectin-carbohydrate interactions: Influence of the linker arm. | |
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Chem. Eur. J. 2012, 18, 6250-6263 | |
Administrative Posts
Chair of South East Asia Dialogue Group
Chair of Pharmacy Extenuating Circumstances Panel
School of Pharmacy Plaigiarism and Collusion officer
Member of School Teaching Executive
Member of School Examinations Board
Module coordinator: Drug Design and Mechanisms of Drug Action
Teaching Interests
I teach Medicinal Chemistry and Molecular pharmaceutics from Year 2 onwards.
Current teaching responsibilities include:
- PHA5001Y Drug Design and Mechanism of Drug Action
- PHA6004Y Evidence based care of Cardiovascular and Renal Disease
- PHA6012Y Therapeutic Approaches to Gastrointestinal Diseases and Cancer
- PHA7001B Neurology and Mental Health
- PHA7003B Special Topics for Pharmacists
- PHA7004Y Pharmaceutical Research Project
Key Research Interests
Research is focused on the interface between chemistry and biology and particularly on the use of supramolecular systems for drug and gene delivery and in novel antibacterial treatments. Current projects include:
- Gene delivery through functionalised multicalixarenes
- Cell imaging using fluorescently labelled macrocycles
- Anti-adhesives as an approach to antibacterial treatment
- Site-specific pro-drug systems for new anti-cancer agents
- New antibiotics related to algae extracts
- New cation and anion receptors based on calixarenes
- Synthesis of new macrocyclic systems
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Chemistry
- Calixarenes
- Cation Binding
- Resorcinarenes
- Anion Binding
- Macrocycles
- Antibacterials
- Drug Delivery
- Multivalency
- Gene Delivery
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Embedding Climate Change and Sustainability in Healthcare Curricula
Matthews, S., Coker, S. & Crozier, K.
15/12/22 → 31/12/23
Project: Other
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Artem Agarkov- Tatarstan scholarship
Ministry of Education and Science of the Republic of Tatarstan
5/01/20 → 4/04/20
Project: Research
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Anton Muravev - Tatarstan Scholarship
Ministry of Education and Science of the Republic of Tatarstan
5/01/20 → 4/04/20
Project: Research
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Developing an Innovative Trans-National Education Approach to the Teaching of Natural Products Chemistry (Phase II).
Matthews, S., Ganesan, A., Mcdermott, P. & Waller, Z.
1/06/19 → 31/12/21
Project: Other
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Pillar[5]arene-based glycoclusters: synthesis and multivalent binding to pathogenic bacterial lectins
Buffet, K., Nierengarten, I., Galanos, N., Gillon, E., Holler, M., Imberty, A., Matthews, S. E., Vidal, S., Vincent, S. P. & Nierengarten, J-F., 24 Feb 2016, In: Chemistry - A European Journal. 22, 9, p. 2955-2963 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)16 Downloads (Pure) -
Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases
Brissonnet, Y., Ortiz Mellet, C., Morandat, S., Garcia Moreno, M. I., Deniaud, D., Matthews, S., Vidal, S., Sestak, S., El Kirat, K. & Gouin, S. G., 13 Nov 2013, In: Journal of the American Chemical Society. 135, 49, p. 18427-18435 9 p.Research output: Contribution to journal › Article › peer-review
78 Citations (Scopus) -
Antiadhesive properties of glycoclusters against Pseudomonas aeruginosa lung infection
Boukerb, A. M., Rousset, A., Galanos, N., Méar, J-B., Thépaut, M., Grandjean, T., Gillon, E., Cecioni, S., Abderrahmen, C., Faure, K., Redelberger, D., Kipnis, E., Dessein, R., Havet, S., Darblade, B., Matthews, S. E., de Bentzmann, S., Guéry, B., Cournoyer, B., Imberty, A. & 1 others, , 24 Nov 2014, In: Journal of Medicinal Chemistry. 57, 24, p. 10275-10289 15 p.Research output: Contribution to journal › Article › peer-review
103 Citations (Scopus) -
Achieving high affinity towards a bacterial lectin through multivalent topological isomers of calix[4]arene glycoconjugates
Cecioni, S., Lalor, R., Blanchard, B., Praly, J-P., Imberty, A., Matthews, S. E. & Vidal, S., 2009, In: Chemistry - A European Journal. 15, 47, p. 13232-13240 9 p.Research output: Contribution to journal › Article › peer-review
163 Citations (Scopus) -
Cellular uptake of a fluorescent calix[4]arene derivative
Lalor, R., Baillie-Johnson, H., Redshaw, C., Matthews, S. E. & Mueller, A., 16 Feb 2008, In: Journal of the American Chemical Society. 130, 10, p. 2892-2893 2 p.Research output: Contribution to journal › Article › peer-review
80 Citations (Scopus)