• 0.19A Biology

Accepting PhD Students

If you made any changes in Pure these will be visible here soon.

Personal profile

Key Research Interests and Expertise

www.grocottlab.com

We study the developing eye to investigate how cells organise themselves into complex organ systems and to expose the root causes of congenital malformations. A central focus of this work is the investigation of gene regulatory networks that define the multitude of ocular cell types and protein regulatory (signal transduction) networks that coordinate their interactive development.

We employ the chick embryo as an experimental model for the vertebrate camera eye. Our multi-disciplinary approach includes: whole-organ (3-D) in vivo imaging and computational analysis to map dynamic regulatory cell states against the emerging anatomy; molecular and pharmacological perturbation and gene expression profiling of micro-dissected tissue explants in vitro to functionally characterise signalling network interactions and their integration with downstream gene regulatory networks; molecular perturbation of gene and protein regulatory networks in vivo to investigate candidate disease genes and validate molecular network topologies.

www.grocottlab.com

 

Academic Background

Our lab website can be found at: www.grocottlab.com

We are on Twitter: @GrocottLab

 

External Activities

  • Fight for Sight Early Career Investigator Award (2011 - 2014)
  • Academy of Medical Sciences Springboard Award (2021 - 2023)

Teaching Interests

  • Skills for Biologists (BIO-4008Y)
  • Cell Biology (BIO-5005B)
  • Embryo Development & Stem Cell Biology (BIO-6012A)
  • Research Project (BIO-6019Y)
  • Frontiers in Molecular Medicine I (BIO-7017A)
  • Molecular Medicine MSc Research Project (BIO-7037X)

 

Network

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or