Projects per year
Personal profile
Key Research Interests
PhD and Research Masters Positions
Please feel free to email me to discuss possible PhD and Research Masters projects.
Research Interests
We study the developing eye to investigate how cells organise themselves into complex organ systems and to expose the root causes of congenital malformations. A central focus of this work is the investigation of gene regulatory networks that define the multitude of ocular cell types and protein regulatory (signal transduction) networks that coordinate their interactive development.
We employ the chick embryo as an experimental model for the vertebrate camera eye. Our multi-disciplinary approach includes: whole-organ (3-D) in vivo imaging and computational analysis to map dynamic regulatory cell states against the emerging anatomy; molecular and pharmacological perturbation and gene expression profiling of micro-dissected tissue explants in vitro to functionally characterise signalling network interactions and their integration with downstream gene regulatory networks; molecular perturbation of gene and protein regulatory networks in vivo to investigate candidate disease genes and validate molecular network topologies.
Academic Background
Teaching Interests
- Course Director: MSc Stem Cells in Development, Disease and Regeneration
- Module Organiser: Embryo Development and Stem Cell Biology (BIO-6012A & BIO-7061A)
I teach on the following modules:
- Skills for Biologists (BIO-4008Y)
- Cell Biology and Physiology (BIO-4015B)
- Cell Biology (BIO-5005B)
- Embryo Development & Stem Cell Biology (BIO-6012A & BIO-7061A)
- Research Project (BIO-6019Y)
- Frontiers in Molecular Medicine I (BIO-7017A)
- MSc Research Project (BIO-7059X)
Projects
- 7 Finished
-
To what extent do Pax7+ neural plate border progenitors contribute to optic vesicle outgrowth
4/07/22 → 28/08/22
Project: Training
-
-
One eye or two? Exploring the requirement of c-Myc in healthy & cyclopic eye development
21/06/21 → 15/08/21
Project: Training
-
Multi-spectral 3D imaging of the developing eye
John & Pamela Salter Charitable Trust (The)
1/10/13 → 30/06/14
Project: Research
-
The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network
Grocott, T., Lozano Velasco, E., Mok, G. F. & Münsterberg, A. E., 23 Dec 2020, In: Development. 147, 24, dev185827.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)20 Downloads (Pure) -
A gene network regulated by FGF signalling during ear development
Anwar, M., Tambalo, M., Ranganathan, R., Grocott, T. & Streit, A., 21 Jul 2017, In: Scientific Reports. 7, 6162.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)20 Downloads (Pure) -
Cell interactions, signals and transcriptional hierarchy governing placode progenitor induction
Hintze, M., Singh Prajapati, R., Tambalo, M., Christophorou, N., Anwar, M., Grocott, T. & Streit, A., 1 Aug 2017, In: Development. 144, 15, p. 2810-2823Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)15 Downloads (Pure) -
Atlas Toolkit: Fast registration of 3D morphological datasets in the absence of landmarks
Grocott, T., Thomas, P. & Munsterberg, A., 11 Feb 2016, In: Scientific Reports. 6, 20732.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)18 Downloads (Pure) -
Chicken as a Developmental Model
Mok, G. F., Alrefaei, A. F., McColl, J., Grocott, T. & Munsterberg, A., 27 Jan 2015, eLS. WileyResearch output: Chapter in Book/Report/Conference proceeding › Chapter
Prizes
-
Academy of Medical Sciences Springboard Award
Grocott, Timothy (Recipient), 2021
Prize: Fellowship awarded competitively
-
Fight for Sight Early Career Investigator Award
Grocott, Timothy (Recipient), 2011
Prize: Fellowship awarded competitively
-
Transforming Education Awards - Staff Member of the Year
Grocott, Timothy (Recipient), 24 Jun 2022
Prize: Prize (including medals and awards)