Projects per year
Key Research Interests
We study the developing eye to investigate how cells organise themselves into complex organ systems and to expose the root causes of congenital malformations. A central focus of this work is the investigation of gene regulatory networks that define the multitude of ocular cell types and protein regulatory (signal transduction) networks that coordinate their interactive development.
We employ the chick embryo as an experimental model for the vertebrate camera eye. Our multi-disciplinary approach includes: whole-organ (3-D) in vivo imaging and computational analysis to map dynamic regulatory cell states against the emerging anatomy; molecular and pharmacological perturbation and gene expression profiling of micro-dissected tissue explants in vitro to functionally characterise signalling network interactions and their integration with downstream gene regulatory networks; molecular perturbation of gene and protein regulatory networks in vivo to investigate candidate disease genes and validate molecular network topologies.
- Fight for Sight Early Career Investigator Award (2011 - 2014)
- Academy of Medical Sciences Springboard Award (2021 - 2023)
- Skills for Biologists (BIO-4008Y)
- Cell Biology (BIO-5005B)
- Embryo Development & Stem Cell Biology (BIO-6012A)
- Research Project (BIO-6019Y)
- Frontiers in Molecular Medicine I (BIO-7017A)
- Molecular Medicine MSc Research Project (BIO-7037X)
1/09/21 → 31/08/23
4/07/22 → 28/08/22
21/06/21 → 15/08/21
The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing networkGrocott, T., Lozano Velasco, E., Mok, G. F. & Münsterberg, A. E., 23 Dec 2020, In: Development. 147, 24, dev185827.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Citations (Scopus)9 Downloads (Pure)
Anwar, M., Tambalo, M., Ranganathan, R., Grocott, T. & Streit, A., 21 Jul 2017, In: Scientific Reports. 7, 6162.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile13 Citations (Scopus)13 Downloads (Pure)
Hintze, M., Singh Prajapati, R., Tambalo, M., Christophorou, N., Anwar, M., Grocott, T. & Streit, A., 1 Aug 2017, In: Development. 144, 15, p. 2810-2823
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile24 Citations (Scopus)9 Downloads (Pure)
Grocott, T., Thomas, P. & Munsterberg, A., 11 Feb 2016, In: Scientific Reports. 6, 20732.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile6 Citations (Scopus)8 Downloads (Pure)