William Fraser

Search results

• 2019

  Zoledronate in the prevention of Paget’s (ZiPP): Protocol for a randomised trial of genetic testing and targeted Zoledronic acid therapy to prevent SQSTM1-mediated Paget’s disease of bone.

  Cronin, O., Forsyth, L., Goodman, K., Lewis, S. C., Keerie, C., Walker, A., Porteous, M., Cetnarskyj, R., Ranganath, L. R., Selby, P. L., Hampson, G., Chandra, R., Ho, S., Tobias, J. H., Young-Min, S., McKenna, M. J., Crowley, R. K., Fraser, W. D., Gennari, L., Nuti, R., & 22 othersBrandi, M. L., del Pino-Montes, J., Devogelaer, J-P., Durnez, A., Isaia, G., di Stefano, M., Guañabens, N., Blanch, J., Seibel, M. J., Walsh, J. P., Kotowicz, M. A., Nicholson, G. C., Duncan, E. L., Major, G., Horne, A., Gilchrist, N. L., Boers, M., Murray, G. D., Charnock, K., Wilkinson, D., Russell, R. G. G. & Ralston, S. H., 4 Sep 2019, In: BMJ Open. 19, e030689.

  Research output: Contribution to journal › Article › peer-review

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  16 Citations (Scopus)

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• 2018

  25-hydroxyvitamin D threshold for the effects of vitamin D supplements on bone density: Secondary analysis of a randomized controlled trial

  Macdonald, H. M., Reid, I. R., Gamble, G. D., Fraser, W. D., Tang, J. C. & Wood, A. D., Aug 2018, In: Journal of Bone and Mineral Research. 33, 8, p. 1464-1469 6 p.

  Research output: Contribution to journal › Article › peer-review

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  90 Citations (Scopus)

  16 Downloads (Pure)

• A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial

  Jennings, A., Cashman, K. D., Gillings, R., Cassidy, A., Tang, J., Fraser, W., Dowling, K. G., Hull, G. L. J., Berendsen, A. A. M., de Groot, L. C. P. G. M., Pietruszka, B., Wierzbicka, E., Ostan, R., Bazzocchi, A., Battista, G., Caumon, E., Meunier, N., Malpuech-Brugère, C., Franceschi, C., Santoro, A., & 1 othersFairweather-Tait, S. J., 1 Sep 2018, In: The American Journal of Clinical Nutrition. 108, 3, p. 633–640 8 p.

  Research output: Contribution to journal › Article › peer-review

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  47 Citations (Scopus)

  28 Downloads (Pure)

• Asfotase Alfa: Interference with ALP-detection systems in immunoassays

  Piec, I., Thompkins, B. & Fraser, W. D., 2018, p. 182.

  Research output: Contribution to conference › Abstract › peer-review

• Bone metabolic responses to low energy availability achieved by diet or exercise in active eumenorrheic women

  Papageorgiou, M., Martin, D., Colgan, H., Cooper, S., Greeves, J. P., Tang, J. C. Y., Fraser, W. D., Elliott-Sale, K. J. & Sale, C., Sep 2018, In: Bone. 114, p. 181-188 8 p.

  Research output: Contribution to journal › Article › peer-review

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  54 Citations (Scopus)

  16 Downloads (Pure)

• Identification of a novel loss-of-function PHEX mutation, Ala720Ser, in a sporadic case of adult-onset hypophosphatemic osteomalacia

  Goljanek-Whysall, K., Tridimas, A., McCormick, R., Russell, N-J., Sloman, M., Sorani, A., Fraser, W. D. & Hannan, F. M., Jan 2018, In: Bone. 106, p. 30-34 5 p.

  Research output: Contribution to journal › Article › peer-review

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  9 Citations (Scopus)

  42 Downloads (Pure)

• Influence of vitamin D supplementation by sunlight or oral D3 on exercise performance

  Carswell, A. T., Oliver, S. J., Wentz, L. M., Kashi, D. S., Roberts, R., Tang, J. C. Y., Izard, R. M., Jackson, S., Allan, D., Rhodes, L. E., Fraser, W. D., Greeves, J. P. & Walsh, N. P., Dec 2018, In: Medicine and Science in Sports and Exercise. 50, 12, p. 2555–2564 10 p.

  Research output: Contribution to journal › Article › peer-review

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  50 Citations (Scopus)

  70 Downloads (Pure)

• SNPs in the vicinity of P2X7R, RANK/RANKL/OPG and Wnt signalling pathways and their association with bone phenotypes in academy footballers

  Varley, I., Hughes, D. C., Greeves, J. P., Fraser, W. D. & Sale, C., Mar 2018, In: Bone. 108, p. 179–185 7 p.

  Research output: Contribution to journal › Article › peer-review

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  13 Citations (Scopus)

  21 Downloads (Pure)

• The association of novel polymorphisms with stress fracture injury in elite athletes: Further insights from the SFEA cohort

  Varley, I., Hughes, D. C., Greeves, J. P., Stellingwerff, T., Ranson, C., Fraser, W. D. & Sale, C., Jun 2018, In: Journal of Science and Medicine in Sport. 21, 6, p. 564-568 5 p.

  Research output: Contribution to journal › Article › peer-review

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  24 Citations (Scopus)

  16 Downloads (Pure)

• The efficacy and mechanism evaluation of treating idiopathic pulmonary fibrosis with the addition of co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial

  Hammond, M., Clark, A. B., Cahn, A. P., Chilvers, E. R., Fraser, W. D., Livermore, D. M., Maher, T. M., Parfrey, H., Swart, A. M., Stirling, S., Thickett, D., Whyte, M. & Wilson, A., 5 Feb 2018, In: Trials. 19, 89.

  Research output: Contribution to journal › Article › peer-review

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  19 Citations (Scopus)

  21 Downloads (Pure)

• The role of small RNAs in Paget's associated osteosarcoma

  Green, D., Dalmay, T. & Fraser, W., 30 Sep 2018, In: Journal of Bone Oncology. 13, p. 54

  Research output: Contribution to journal › Abstract › peer-review

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• Vitamin D insufficiency and elevated vitamin D metabolite ratios (VMR) are associated with increased risk of injuries: Results from the British Army Lower Limb Iinjury Pprevention (ALLIP) study

  Tang, J., Jackson, S., Izard, R., Oliver, S., Piec, I., Washbourne, C., Walsh, N., Greeves, J. & Fraser, W., 2018, In: Journal of Bone and Mineral Research. 59

  Research output: Contribution to journal › Abstract › peer-review

• Vitamin D to prevent lung injury following esophagectomy: A randomized, placebo-controlled trial

  Parekh, D., Dancer, R. C. A., Scott, A., D'Souza, V. K., Howells, P. A., Mahida, R. Y., Tang, J. C. Y., Cooper, M. S., Fraser, W. D., Tan, L., Gao, F., Martineau, A. R., Tucker, O., Perkins, G. D. & Thickett, D. R., Dec 2018, In: Critical Care Medicine. 46, 12, p. e1128–e1135 8 p.

  Research output: Contribution to journal › Article › peer-review

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  41 Citations (Scopus)

  23 Downloads (Pure)
• 2017

  A LC-MS/MS method for the diagnostic measurement of cAMP in plasma and urine

  Piec, I., Dutton, J., Al Riyami, S., Washbourne, C., Schoenmakers, I., Galitzer, H., Burshtein, G., Schwartz, P., Tang, J. C. Y. & Fraser, W., 9 Sep 2017.

  Research output: Contribution to conference › Poster › peer-review

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• Assessment of vitamin D status using Mitra (TM) volumetric absorptive microsampling (VAMS) device

  Tang, J., Nicholls, H., Ball, N., Dutton, J., Piec, I., Rudge, J., Washbourne, C. & Fraser, W., 2017, p. S156.

  Research output: Contribution to conference › Abstract › peer-review

• Assessment of vitamin D status using Mitra^TM volumetric absorptive microsampling (VAMS) device

  Tang, J. C. Y., Nicholls, H., Ball, N., Dutton, J., Piec, I., Rudge, J., Washbourne, C. & Fraser, W., 9 Sep 2017.

  Research output: Contribution to conference › Poster › peer-review

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• Autoantibodies to osteoprotegerin are associated with low hip bone mineral density and history of fractures in axial spondyloarthritis: A cross-sectional observational study

  Hauser, B., Zhao, S., Visconti, M. R., Riches, P. L., Fraser, W. D., Piec, I., Goodson, N. J. & Ralston, S. H., Oct 2017, In: Calcified Tissue International. 101, 4, p. 375–383 9 p.

  Research output: Contribution to journal › Article › peer-review

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  25 Citations (Scopus)

  11 Downloads (Pure)

• Development and Validation of a LC-MS/MS Assay for Quantification of Parathyroid Hormone (PTH 1-34) in human Plasma

  Al Riyami, S., Tang, J. C. Y., Dutton, J., Washbourne, C., Galitzer, H. & Fraser, W., 10 Sep 2017.

  Research output: Contribution to conference › Poster › peer-review

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• Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?

  Hanusch, B. C., Tuck, S. P., McNally, R. J. Q., Wu, J. J., Prediger, M., Walker, J., Tang, J., Piec, I., Fraser, W. D., Datta, H. K. & Francis, R. M., Oct 2017, In: Osteoporosis International. 28, 10, p. 2877–2886 10 p.

  Research output: Contribution to journal › Article › peer-review

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  10 Citations (Scopus)

  23 Downloads (Pure)

• Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism – a randomised controlled study

  Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Kilpatrick, E. S. & Atkin, S. L., 13 Nov 2017, In: Scientific Reports. 7, 15366.

  Research output: Contribution to journal › Article › peer-review

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  8 Citations (Scopus)

  11 Downloads (Pure)

• Effects of reduced energy availability on bone metabolism in women and men

  Papageorgiou, M., Elliott-Sale, K. J., Parsons, A., Tang, J., Greeves, J. P., Fraser, W. D. & Sale, C., Dec 2017, In: Bone. 105, p. 191-199

  Research output: Contribution to journal › Article › peer-review

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  113 Citations (Scopus)

  20 Downloads (Pure)

• Efficacy of high-dose vitamin D supplements for elite athletes

  Owens, D. J., Tang, J. C. Y., Bradley, W. J., Sparks, S. A., Fraser, W. D., Morton, J. P. & Close, G. L., Feb 2017, In: Medicine and Science in Sports and Exercise. 49, 2, p. 349–356 8 p.

  Research output: Contribution to journal › Article › peer-review

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  47 Citations (Scopus)

  25 Downloads (Pure)

• Enhanced bioavailability and reduced pharmacokinetic variability of Oral PTH (1-34) in man

  Burstein, G., Tang, J. C. Y., Rothner, A., Galitzer, H., Schwartz, P. & Fraser, W., 11 Sep 2017.

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• Habitual levels of higher, but not medium or low, impact physical activity are positively related to lower limb bone strength in older women: Findings from a population-based study using accelerometers to classify impact magnitude

  Hannam, K., Deere, K. C., Hartley, A., Al-Sari, U. A., Clark, E. M., Fraser, W. D. & Tobias, J. H., Oct 2017, In: Osteoporosis International. 28, 10, p. 2813–2822

  Research output: Contribution to journal › Article › peer-review

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  44 Citations (Scopus)

  15 Downloads (Pure)

• Harmonization study between LC-MS/MS and Diasorin RIA for measurement of 25-hydroxyvitamin D concentrations in a large population survey

  Berry, D. J., Dutton, J., Fraser, W. D., Järvelin, M-R. & Hyppönen, E., May 2017, In: Journal of Clinical Laboratory Analysis. 31, 3, e22049.

  Research output: Contribution to journal › Article › peer-review

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  13 Citations (Scopus)

  12 Downloads (Pure)

• Heavy cannabis use is associated with low bone mineral density and an increased risk of fractures

  Sophocleous, A., Robertson, R., Ferreira, N. B., McKenzie, J., Fraser, W. D. & Ralston, S. H., Feb 2017, In: American Journal of Medicine. 130, 2, p. 214-221 8 p.

  Research output: Contribution to journal › Article › peer-review

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  59 Citations (Scopus)

  9 Downloads (Pure)

• High Bone Mass is associated with bone-forming features of osteoarthritis in non-weight bearing joints independent of body mass index

  Gregson, C. L., Hardcastle, S. A., Murphy, A., Faber, B., Fraser, W. D., Williams, M., Davey Smith, G. & Tobias, J. H., Apr 2017, In: Bone. 97, p. 306–313 8 p.

  Research output: Contribution to journal › Article › peer-review

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  11 Citations (Scopus)

  13 Downloads (Pure)

• Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency

  Saleh, L., Tang, J. CY., Gawinecka, J., Boesch, L., Fraser, W. D., von Eckardstein, A. & Nowak, A., 26 Oct 2017, In: Clinical Chemistry and Laboratory Medicine. 55, 12, p. 1912-1921 10 p.

  Research output: Contribution to journal › Article › peer-review

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  9 Citations (Scopus)

  18 Downloads (Pure)

• Increased training volume improves bone density and cortical area in adolescent football players

  Varley, I., Hughes, D. C., Greeves, J. P., Fraser, W. & Sale, C., May 2017, In: International Journal of Sports Medicine. 38, 5, p. 341-346 6 p.

  Research output: Contribution to journal › Article › peer-review

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  26 Citations (Scopus)

  13 Downloads (Pure)

• LC-MS/MS measurement of parathyroid hormone PTH (1-34): Use in studying oral PTH (1-34) administration and possible diagnostic application in pseudohypoparathyroidism.

  Al Riyami, S., Tang, J. C. Y., Galitzer, H. & Fraser, W., 6 Nov 2017, p. 70.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

• Longevity of daily oral Vitamin D3 supplementation: Differences in 25OHD and 24,25(OH)2D observed 2 years after cessation of a 1-year randomized controlled trial (VICtORy RECALL)

  Macdonald, H. M., Gryka, A., Tang, J. C. Y., Aucott, L. S., Fraser, W. D. & Wood, A. D., Dec 2017, In: Osteoporosis International. 28, 12, p. 3361–3372 12 p.

  Research output: Contribution to journal › Article › peer-review

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  7 Citations (Scopus)

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• Long-term randomized trial of intensive versus symptomatic management in Paget's disease of bone: The PRISM-EZ study

  Tan, A., Goodman, K., Walker, A., Hudson, J., MacLennan, G. S., Selby, P. L., Fraser, W. D., Ralston, S. H. & PRISM-EZ Trial Group, Jun 2017, In: Journal of Bone and Mineral Research. 32, 6, p. 1165–1173 9 p.

  Research output: Contribution to journal › Article › peer-review

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  47 Citations (Scopus)

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• Measurements of Osteoanabolic agents PTH (1-34) and PTHrP (1-36) in therapeutic studies and clinical diagnostics

  Al Riyami, S., Tang, J. C. Y., Galitzer, H. & Fraser, W., 10 Sep 2017.

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• MicroRNA expression in a phosphaturic mesenchymal tumour

  Green, D., Mohorianu, I., Piec, I., Turner, J., Beadsmoore, C., Toms, A., Ball, R., Nolan, J., McNamara, I., Dalmay, T. & Fraser, W. D., Dec 2017, In: Bone Reports. 7, p. 63–69 7 p.

  Research output: Contribution to journal › Article › peer-review

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  5 Citations (Scopus)

  33 Downloads (Pure)

• miR-16 is highly expressed in Paget’s associated osteosarcoma

  Green, D., Mohorianu, I., McNamara, I., Dalmay, T. & Fraser, W. D., 1 May 2017, In: Endocrine-Related Cancer (ERC). 24, 5, p. L27-L31

  Research output: Contribution to journal › Letter › peer-review

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  8 Citations (Scopus)

  17 Downloads (Pure)

• Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa

  Kishnani, P. S., Rush, E. T., Arundel, P., Bishop, N., Dahir, K., Fraser, W., Harmatz, P., Linglart, A., Munns, C. F., Nunes, M. E., Saal, H. M., Seefried, L. & Ozono, K., Sep 2017, In: Molecular Genetics and Metabolism. 122, 1-2, p. 4–17

  Research output: Contribution to journal › Article › peer-review

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  85 Citations (Scopus)

  67 Downloads (Pure)

• Perspective and priorities for improvement of parathyroid hormone (PTH) measurement – A view from the IFCC Working Group for PTH

  Sturgeon, C. M., Sprague, S., Almond, A., Cavalier, E., Fraser, W. D., Algeciras-Schimnich, A., Singh, R., Souberbielle, J-C., Vesper, H. W. & IFCC Working Group for PTH, Apr 2017, In: Clinica Chimica Acta. 467, p. 42-47 6 p.

  Research output: Contribution to journal › Article › peer-review

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• Reduced fetal vitamin D status by maternal undernutrition during discrete gestational windows in sheep

  Cleal, J. K., Hargreaves, M. R., Poore, K. R., Tang, J. C. Y., Fraser, W. D., Hanson, M. A. & Green, L. R., Jun 2017, In: Journal of Developmental Origins of Health and Disease. 8, 3, p. 370-381 12 p.

  Research output: Contribution to journal › Article › peer-review

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  6 Citations (Scopus)

  12 Downloads (Pure)

• Reference intervals for serum 24,25-dihydroxyvitamin D and the ratio with 25-hydroxyvitamin established using a newly developed LC-MS/MS method

  Tang, J. C. Y., Nicholls, H., Piec, I., Washbourne, C. J., Dutton, J. J., Jackson, S., Greeves, J. & Fraser, W. D., Aug 2017, In: Journal of Nutritional Biochemistry. 46, p. 21–29 9 p.

  Research output: Contribution to journal › Article › peer-review

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  86 Citations (Scopus)

  27 Downloads (Pure)

• Soy reduces bone turnover markers in women during early menopause: A randomized controlled trial

  Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S. & Atkin, S. L., Jan 2017, In: Journal of Bone and Mineral Research. 32, 1, p. 157–164 8 p.

  Research output: Contribution to journal › Article › peer-review

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  49 Citations (Scopus)

  16 Downloads (Pure)

• The effect of postexercise carbohydrate and protein ingestion on bone metabolism

  Townsend, R., Elliott-Sale, K. J., Currell, K., Tang, J., Fraser, W. D. & Sale, C., Jun 2017, In: Medicine & Science in Sports & Exercise. 49, 6, p. 1209-1218 10 p.

  Research output: Contribution to journal › Article › peer-review

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  35 Citations (Scopus)

  13 Downloads (Pure)

• The effect of short-term vitamin D supplementation on hypercalcaemic vitamin D insufficient renal transplant recipients

  Lynch Cronin, I., Byrne, F., Doyle, R., Chipchase, A., Fraser, W. & Eustace, J., 26 May 2017, In: Nephrology Dialysis Transplantation. 32, suppl_3, p. iii239 SP377.

  Research output: Contribution to journal › Abstract

• The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

  Jamil, N. A., Gray, S. R., Fraser, W. D., Fielding, S. & Macdonald, H. M., Apr 2017, In: Osteoporosis International. 28, 4, p. 1433–1443 11 p.

  Research output: Contribution to journal › Article › peer-review

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  5 Citations (Scopus)

  23 Downloads (Pure)

• Vitamin D deficiency in human and murine sepsis

  Parekh, D., Patel, J. M., Scott, A., Lax, S., Dancer, R. C. A., D’Souza, V., Greenwood, H., Fraser, W. D., Gao, F., Sapey, E., Perkins, G. D. & Thickett, D. R., Feb 2017, In: Critical Care Medicine. 45, 2, p. 282–289

  Research output: Contribution to journal › Article › peer-review

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  51 Citations (Scopus)

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• Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England

  Earl, K. E., Sakellariou, G. K., Sinclair, M., Fenech, M., Croden, F., Owens, D. J., Tang, J., Miller, A., Lawton, C., Dye, L., Close, G. L., Fraser, W. D., McArdle, A. & Beadsworth, M. B. J., 1 Nov 2017, In: BMJ Open. 7, e015296.

  Research output: Contribution to journal › Article › peer-review

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  12 Citations (Scopus)

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• β-alanine supplementation improves in-vivo fresh and fatigued skeletal muscle relaxation speed

  Jones, R. L., Barnett, C. T., Davidson, J., Maritza, B., Fraser, W. D., Harris, R. & Sale, C., May 2017, In: European Journal of Applied Physiology. 117, 5, p. 867–879

  Research output: Contribution to journal › Article › peer-review

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  15 Citations (Scopus)

  8 Downloads (Pure)
• 2016

  c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines

  Pacheco-Pantoja, E. L., Dillon, J. P., Wilson, P. J. M., Fraser, W. D. & Gallagher, J. A., Dec 2016, In: Purinergic Signalling. 12, 4, p. 647–651 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  13 Citations (Scopus)

  10 Downloads (Pure)

• Chronic kidney disease bone disease

  Piec, I., Chipchase, A., Nicholls, H., Washbourne, C., Tang, J. & Fraser, W. D., 2016, p. i460. 1 p.

  Research output: Contribution to conference › Poster

• Circadian rhythm of oestradiol: Impact on the bone metabolism of adult males

  Wijetilleka, S., Mon, A., Khan, M., Joseph, F., Robinson, A., Vora, J. P. & Fraser, W. D., 26 Aug 2016, In: Journal of Clinical and Molecular Endocrinology. 1, 20.

  Research output: Contribution to journal › Article › peer-review

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• Evidence that genetic variants within a regulatory region of chromosome 1p13 predispose to Paget’s disease of bone by regulating production of macrophage-colony stimulating factor

  Abdullah, M. F., Jin, H., Tang, J., Piec, I., Fraser, W. D., Albagha, O. M. E. & Ralston, S. H., 2016.

  Research output: Contribution to conference › Poster › peer-review