Projects per year
Yaroslav Khimyak has moved to a Chair in solid-state NMR spectroscopy in the School of Pharmacy in UEA in September 2011. Until then he was a Senior Lecturer at the Department of Chemistry in the University of Liverpool where he was appointed as a Lecturer in 2002. Yaroslav graduated from Ivan Franko Lviv State University in the Ukraine with an M.Sc. in Chemistry (1994), obtained an M. Phil. (1997) and a Ph. D. (2000) from the University of Cambridge and held a position of Oppenheimer Research Fellow at the Department of Chemistry in the University of Cambridge (1999 – 2002).
Research in YK’s group focuses on the understanding of structure and dynamics of materials with limited long range ordering using advanced NMR. The materials of interest include pharmaceutical solids (Mol. Pharm, 2016, 1012; 2015, 2981), polymers Angew. Chem. Int. Ed. 2011, 1072; 2007, 8574) and porous materials (Angew. Chem. Int. Ed., 2016, 8904; Science, 2010, 1053; J. Am. Chem. Soc., 2012, 20466; Nature Mater., 2014, 343; EP/J008834/1, EP/F057865/1). We have developed an NMR based methods for soft matter and heterogeneous materials where the understanding of intermolecular interactions is a considerable challenge and a complex approach based on the application of different methodologies is required (Chem. Eur. J., 2017, 8014; Soft Matter, 2016, 4034). The recent award of the EPSRC/Innovate UK grant “New Enzymatically Produced Interpenetrating Starch-Cellulose Gels” (EP/N033337/1, £2.8 M across UEA, JIC and Universities of Bristol and Bath) aims to develop an advanced NMR toolkit for soft materials.
Yaroslav Khimyak is the Head of the NMR steering group in NRP, a member of the Core Team of EPSRC Directed Assembly network, a member of RSC NMR DG committee and a member of Materials Focus group in the Academy of Pharmaceutical Sciences and a Consultant in NMR Crystallography Commission of the International Union of Crystallography.
An Adaptable Peptide-Based Porous Material
J. Rabone, Y. F. Yue, S. Y. Chong, K. C. Stylianou, J. Bacsa, D. Bradshaw, G. R. Darling, N. G. Berry, Y. Z. Khimyak, A. Y. Ganin, P. Wiper, J. B. Claridge, and M. J. Rosseinsky.
Science, 2010, 329, 1053-1057.
Effect of encapsulating a pseudo-decapeptide containing arginine on PLGA: a solid-state NMR study
J. B. Guilbaud, B. C. Clark, E. Meehan, L. Hughes, A. Saiani and Y. Z. Khimyak.
Journal of Pharmaceutical Sciences, 2010, 99, 2697-2710.
Amorphous Drug-PVP Dispersions: Application of Theoretical, Thermal and Spectroscopic Analytical Techniques to the Study of a Molecule with Intermolecular Bonds in Both the Crystalline and Pure Amorphous State
M. Tobyn, J. Brown, A. B. Dennis, M. Fakes, Q. Gao, J. Gamble, Y. Z. Khimyak, G. McGeorge, C. Patel, W. Sinclair, P. Timmins and S. Yin
Journal of Pharmaceutical Sciences, 2009, 98, 3456-3468.
Periodic mesoporous organosilicas with domain functionality: Synthesis and advanced characterization
J. T. A. Jones, C. D. Wood, C. Dickinson and Y. Z. Khimyak
Chemistry of Materials, 2008, 20, 3385-3397.
Nuclear magnetic resonance and related methods for characterisation of advanced materials including pharmaceuticals; materials for drug delivery - design and advanced characterisation; soft solids and porous materials - molecular level structure and dynamics.
Head of Pharmaceutical Materials and Drug Delivery Section
NRP/DTP Studentship on Plant Cell Wall Hydrogels
NRP/DTP Studentship on UNderstanding Lipid Digestion using NMR
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Lettice, F., Alexander, M., Askounis, A., Baker, A., Cammidge, A., Chao, Y., Fabian, L., Fielden, J., Hernaez Saenz De Zaitigui, M., Hui, O., Kaplani, E., Khimyak, Y., Liss, P., Lord, R., Marin, M. J., Mayes, A., Melendi-Espina, S., Nolte, S., Romanov, A., Saeed, A., Sobolewski, A., Tolhurst, T. & Wright, J.
6/11/20 → 5/05/22
15/11/18 → 14/11/21
1/10/17 → 31/12/20
1/02/17 → 30/04/18
1/09/16 → 30/11/20
Supramolecular amino acid based hydrogels: probing the contribution of additive molecules using NMR spectroscopyRamalhete, S., Nartowski, K., Sarathchandra, N., Foster, J., Round, A., Angulo, J., Lloyd, G. & Khimyak, Y., 12 Jun 2017, In : Chemistry - A European Journal. 23, 33, p. 8014–8024
Research output: Contribution to journal › ArticleOpen AccessFile26 Citations (Scopus)23 Downloads (Pure)
19F NMR spectroscopy as a highly sensitive method for the direct monitoring of confined crystallization within nanoporous materialsNartowski, K., Malhotra, D., Hawarden, L., Sibik, J., Iuga, D., Zeitler, J. A., Fabian, L. & Khimyak, Y., 25 Jul 2016, In : Angewandte Chemie International Edition. 128, 31, p. 9050-9054 5 p.
Research output: Contribution to journal › ArticleOpen AccessFile20 Citations (Scopus)23 Downloads (Pure)
Substituent interference on supramolecular assembly in urea gelators: synthesis, structure prediction and NMRPiana, F., Case, D. H., Campos E Menezes Jorge Ramalhete, S., Pileio, G., Facciotti, M., Day, G. M., Khimyak, Y., Angulo, J., Brown, R. C. D. & Gale, P. A., 7 May 2016, In : Soft Matter. 12, 17, p. 4034-4043 12 p.
Research output: Contribution to journal › ArticleOpen AccessFile21 Citations (Scopus)11 Downloads (Pure)
Khimyak, Y. & Berry, D., 21 Apr 2016, In : CrystEngComm. 18, 15, p. 2617-2620 4 p.
Research output: Contribution to journal › ArticleOpen AccessFile9 Citations (Scopus)13 Downloads (Pure)
Khimyak, Y., Morris, K., Byrn, S. & Griesser, U., 7 Mar 2016, In : Molecular Pharmaceutics. 13, 3, p. 1012-1029 18 p.
Research output: Contribution to journal › ArticleOpen AccessFile19 Citations (Scopus)9 Downloads (Pure)
Chemoenzymatic synthesis of fluorinated cellodextrins identifies a new allomorph for cellulose‐like materials
Muñoz-García, J. C. (Creator), de Andrade, P. (Contributor), Pergolizzi, G. (Contributor), Gabrielli, V. (Contributor), Nepogodiev, S. (Contributor), Iuga, D. (Contributor), Fabian, L. (Contributor), Nigmatullin, R. (Contributor), Johns, M. A. (Contributor), Harniman, R. (Contributor), Eichhorn, S. J. (Contributor), Angulo, J. (Contributor), Khimyak, Y. (Contributor) & Field, R. A. (Contributor), Wiley-VCH, Weinheim, 30 Sep 2020
Data for Rapid determination of the acidity, alkalinity and carboxyl content of aqueous samples by 1H NMR with minimal sample quantity
Data for: Understanding heat driven gelation of anionic cellulose nanofibrils: Combining saturation transfer difference (STD) NMR, small angle X-ray scattering (SAXS) and rheology
Calabrese, V. (Creator), Muñoz-García, J. C. (Creator), Schmitt, J. (Creator), da Silva, M. A. (Creator), Scott, J. L. (Creator), Angulo, J. (Creator), Khimyak, Y. (Creator) & Edler, K. J. (Creator), University of East Anglia, 2018
Khimyak, Y. (Creator), UEA, 3 Oct 2019