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Personal profile

Administrative Posts

  • SSS theme lead for Nutrition.
  • Co-theme Lead for Nutrition teaching in MBBS.

External Activities

  • Visiting Professor (PhD supervisor), Harbin Medical University, China (2003).
  • Editorial Board member: Biophysics Reports; Food Chemistry; Free Radical Biology & Medicine; Molecular Medicine Reports; Oncology Reports.
  • Associae Editor: Food Chemistry Advances (2021).

Professional Activities

  • Fellow of the the Royal Society of Chemistry (FRSC) 2009.
  • Fellow of the Higher Education Academy (FHEA) 2021.
  • Grant reviewer for BBSRC, MRC, CRUK, NSFC and SFS.

Career

  • Reader, University of East Anglia, August 2014-present
  • Senior Lecturer, University of East Anglia, August 2008-July 2014.
  • Lecturer, University of East Anglia, March 2005-2008.
  • Senior Scientist, Institute of Food Research, Norwich 2000-Feb 2005.
  • Research Scientist, Institute of Food Research, Norwich 1996-2000.
  • Lecturer, Harbin Medical University, China 1988-1992.
     

Specialisms

Phytochemicals; isothiocyanates; selenium; gene expression; cancer prevention.

Academic Background

  • PhD, University of East Anglia, 1996.
  • M.Med, School of Public Health, Harbin Medical University, China 1987.
  • B.Med, Harbin Medical University, China 1983.

 

Biography

I began my career at Harbin Medical University where I graduated with M.B. in Preventative Medicine, Master in Nutrition and a Lecturer for 4 years. During my PhD study at the Institute of Food Research (IFR), Norwich I developed a specific assay for a selenium dependent glutathione peroxidase (GPX4). After my PhD, I worked as Research Scientist and Senior Research Scientist at IFR. My research focused on chemopreventive activities of dietary phytochemicals. I moved to School of Medicine, UEA in March 2005 as a Lecturer.

 

Key Research Interests:

  • Mechanisms of phytochemicals in cancer prevention.
  • Interactions between isothiocyanates and selenium in selenoprotein gene expression.
  • Bioactivity of nanoencapsulated phytochemicals. 

Key Research Interests and Expertise

  • Mechanisms of phytochemicals in cancer chemo-prevention.
  • Interactions between isothiocyanates and selenium in selenoprotein gene expression.
  • Bioactivity of nanoencapsulated phytochemicals and anti-cancer drugs. 

 

 

Selected Recent Publications:

  1. Wang Q and Bao Y. Nanodelivery of Natural Isothiocyanates as Cancer Therapeutic Free Rad Bio Med.2021,167;125-140. DOI: 10.1016/j.freeradbiomed.2021.02.044 

  2. Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y, Qi Y, Shi J, Qi S, Bao Y, Nie G. Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity. ACS Nano. 2019 Nov 4. doi: 10.1021/acsnano.9b07032.
  3. Liu P, Behray M, Wang Q, Wang W, Zhou Z, Chao Y, Bao Y. Anti-cancer activities of allyl isothiocyanate and its conjugated silicon quantum dots. Sci Rep. 2018; 8:1084. doi: 10.1038/s41598-018-19353-7.

  4. Tian S, Li B, Lei P, Yang X, Zhang X, Bao Y, Shan Y. Sulforaphane regulates abnormal lipid metabolism via both ERS-dependent XBP1/ACC & SCD1 and ERS-independent SREBP/FAS pathways. Mol Nutr Food Res. 2018 Jan 30. doi: 10.1002/mnfr.201700737. [Epub ahead of print].

  5. Liu P, Atkinson SJ, Akbareian SE, Zhou Z, Munsterberg A, Robinson, SD, Bao Y. Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF1-α/VEGF signalling. Sci Rep. 2017; 7(1):12651. doi: 10.1038/s41598-017-12855-w.

  6. Zhang HQ, Chen SY, Wang AS, Yao AJ, Fu JF, Zhao JS, Chen F, Zou ZQ, Zhang XH, Shan YJ, Bao YP. Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization. Mol Nutr Food Res. 2016; 60(10):2185-2197. doi: 10.1002/mnfr.201500915.

https://scholar.google.co.uk/citations?user=GDRJ1p8AAAAJ&hl=en

https://www.scopus.com/authid/detail.uri?authorId=7202213522

 

Key Responsibilities

 SSS theme lead for Nutrition

Teaching Interests

My teaching is mainly focussed on the MB/BS medical degree course. My teaching interests are in providing medical students with an understanding of the basic nutritional requirements and the diet and prevention of chronic diseases including cancer, CVD and diabetes.  Another interest is the teaching of lab-based research projects, nutritional clinical skills and dietary assessment.

Expertise related to UN Sustainable Devlopment Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Network

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