Projects per year
Personal profile
Career
- Professor, University of East Anglia, August 2022-present.
- Reader, University of East Anglia, August 2014-July 2022.
- Lecturer/Senior Lecturer, University of East Anglia, March 2005-July 2014.
- Senior Scientist, Institute of Food Research, Norwich 2000-Feb 2005.
- Research Scientist, Institute of Food Research, Norwich 1996-2000.
- Lecturer, Harbin Medical University, China 1988-1992.
Areas of Expertise
Phytochemicals; isothiocyanates; selenium; gene expression; cancer prevention.
Academic Background
- PhD, University of East Anglia, 1996.
- M.Med, School of Public Health, Harbin Medical University, China 1987.
- B.Med, Harbin Medical University, China 1983.
Biography
I began my career at Harbin Medical University where I graduated with M.B. in Preventative Medicine, Master in Nutrition and a Lecturer for 4 years. During my PhD study at the Institute of Food Research (IFR), Norwich I developed a specific assay for a selenium dependent glutathione peroxidase (GPX4). After my PhD, I worked as Research Scientist and Senior Research Scientist at IFR. My research focused on chemopreventive activities of dietary phytochemicals. I moved to School of Medicine, UEA in March 2005 as a Lecturer.
Key Research Interests:
- Mechanisms of phytochemicals in cancer prevention.
- Interactions between isothiocyanates and selenium in selenoprotein gene expression.
- Bioactivity of nanoencapsulated phytochemicals.
Key Research Interests
- Mechanisms of phytochemicals in cancer chemo-prevention.
- Interactions between isothiocyanates and selenium in selenoprotein gene expression.
- Bioactivity of nanoencapsulated phytochemicals and anti-cancer drugs.
Selected Recent Publications:
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Wang Q and Bao Y. Nanodelivery of Natural Isothiocyanates as Cancer Therapeutic Free Rad Bio Med.2021,167;125-140. DOI: 10.1016/j.freeradbiomed.2021.02.044
- Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y, Qi Y, Shi J, Qi S, Bao Y, Nie G. Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity. ACS Nano. 2019 Nov 4. doi: 10.1021/acsnano.9b07032.
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Liu P, Behray M, Wang Q, Wang W, Zhou Z, Chao Y, Bao Y. Anti-cancer activities of allyl isothiocyanate and its conjugated silicon quantum dots. Sci Rep. 2018; 8:1084. doi: 10.1038/s41598-018-19353-7.
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Tian S, Li B, Lei P, Yang X, Zhang X, Bao Y, Shan Y. Sulforaphane regulates abnormal lipid metabolism via both ERS-dependent XBP1/ACC & SCD1 and ERS-independent SREBP/FAS pathways. Mol Nutr Food Res. 2018 Jan 30. doi: 10.1002/mnfr.201700737. [Epub ahead of print].
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Liu P, Atkinson SJ, Akbareian SE, Zhou Z, Munsterberg A, Robinson, SD, Bao Y. Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF1-α/VEGF signalling. Sci Rep. 2017; 7(1):12651. doi: 10.1038/s41598-017-12855-w.
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Zhang HQ, Chen SY, Wang AS, Yao AJ, Fu JF, Zhao JS, Chen F, Zou ZQ, Zhang XH, Shan YJ, Bao YP. Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization. Mol Nutr Food Res. 2016; 60(10):2185-2197. doi: 10.1002/mnfr.201500915.
https://scholar.google.co.uk/citations?user=GDRJ1p8AAAAJ&hl=en
https://www.scopus.com/authid/detail.uri?authorId=7202213522
Teaching Interests
My teaching is mainly focussed on the MB/BS medical degree course. My teaching interests are in providing medical students with an understanding of the basic nutritional requirements and the diet and prevention of chronic diseases including cancer, CVD and diabetes. Another interest is the teaching of lab-based research projects, nutritional clinical skills and dietary assessment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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Phytochemicals and cancer prevention
Cancer Prevention Research Trust
1/10/23 → 30/09/26
Project: Research
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Anti-cancer activity of dietary phytochemicals (Nuha Sinky - PhD studentship)
1/02/21 → 31/01/24
Project: Research
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Hormetic phytochemicals in cancer prevention
Cancer Prevention Research Trust
1/01/20 → 31/12/23
Project: Research
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Combination of phenethyl isothiocyanate and dasatinib inhibits hepatocellular carcinoma metastatic potential through FAK/STAT3/Cadherin signalling and reduction of VEGF secretion
Strusi, G., Suelzu, C. M., Weldon, S., Giffin, J., Münsterberg, A. E. & Bao, Y., Oct 2023, In: Pharmaceutics. 15, 10, 2390.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Dietary isothiocyanates: Novel insights into the potential for cancer prevention and therapy
Na, G., He, C., Zhang, S., Tian, S., Bao, Y. & Shan, Y., 1 Feb 2023, In: International Journal of Molecular Sciences. 24, 3, 1962.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)7 Downloads (Pure) -
Phenethyl isothiocyanate and dasatinib combination synergistically reduces hepatocellular carcinoma growth via cell cycle arrest and oxeiptosis
Strusi, G., Suelzu, C., Horwood, N., Münsterberg, A. E. & Bao, Y., 4 Oct 2023, In: Frontiers in Pharmacology. 14, 1264032.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Sulforaphane inhibits foam cell formation and atherosclerosis via mechanisms involving the modulation of macrophage cholesterol transport and the related phenotype
Liu, S., Zhang, Y., Zheng, X., Wang, Z., Wang, P., Zhang, M., Shen, M., Bao, Y. & Li, D., May 2023, In: Nutrients. 15, 9, 2117.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics
Wang, Y., Chen, F., Zhang, Y., Zheng, X., Liu, S., Tang, M., Wang, Z., Wang, P., Bao, Y. & Li, D., 7 Mar 2022, In: Food & Function. 13, 5, p. 2884-2898 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)
Activities
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Higher Education Academy (External organisation)
Yongping Bao (Fellow)
2021 → …Activity: Membership › External research organisation
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Food Chemistry Advances (Journal)
Yongping Bao (Associate Editor)
2021Activity: Editorial work › Publication editorial role
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Free Radical Biology & Medicine (Journal)
Yongping Bao (Editorial board member)
2020 → …Activity: Editorial work › Publication editorial role
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Molecular Medicine Reports (Journal)
Yongping Bao (Editorial board member)
2019 → …Activity: Editorial work › Publication editorial role
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Oncology Reports (Journal)
Yongping Bao (Editorial board member)
2019 → …Activity: Editorial work › Publication editorial role