Biological roles and mechanisms of nitric oxide reactions with iron-sulfur cluster transcriptional regulators

Le Brun, Nick (Principal Investigator)
Hutchings, Matt (Co-Investigator)
Thomson, Andrew (Co-Investigator)
Cull, Nicholas (Technician)

Status	Finished
Effective start/end date	1/07/12 → 30/06/15

Funding

Biotechnology and Biological Sciences Research Council: £352,620.00

8 Article

Crystal structure of the transcription regulator RsrR reveals a [2Fe-2S] cluster coordinated by Cys, Glu and His residues
Volbeda, A., Pellicer Martinez, M. T., Crack, J. C., Amara, P., Gigarel, O., Munnoch, J. T., Hutchings, M. I., Darnault, C., Le Brun, N. E. & Fontecilla-Camps, J. C., 13 Feb 2019, In: Journal of the American Chemical Society. 141, 6, p. 2367–2375 9 p.
Research output: Contribution to journal › Article › peer-review

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7 Citations (Scopus)

6 Downloads (Pure)
Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA
Pellicer Martinez, M. T., Crack, J., Stewart, M., Bradley, J., Svistunenko, D. A., Johnston, A., Cheesman, M., Todd, J. & Le Brun, N., 17 Sep 2019, In: eLife. 8, e47804.
Research output: Contribution to journal › Article › peer-review

Open Access
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5 Citations (Scopus)

18 Downloads (Pure)
Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding
Volbeda, A., Dodd, E. L., Darnault, C., Crack, J. C., Renoux, O., Hutchings, M. I., Le Brun, N. E. & Fontecilla-Camps, J. C., 20 Apr 2017, In: Nature Communications. 8, 15052.
Research output: Contribution to journal › Article › peer-review

Open Access
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31 Citations (Scopus)

10 Downloads (Pure)