Combining Click Chemistry & Peptide Synthesis to Generate Novel Inhibitors of the Anti-Apoptotic Protein Mcl-1 for the Treatment of Pancreatic Cancer.

Howell, Lesley (Principal Investigator)

School of Chemistry, Pharmacy and Pharmacology

Status	Finished
Effective start/end date	31/03/15 → 29/06/16

Funding

Engineering and Physical Sciences Research Council: £101,192.00

2 Article
1 Letter

Singular location and signaling profile of adenosine A2A-cannabinoid CB1 receptor heteromers in the dorsal striatum
Moreno, E., Chiarlone, A., Medrano, M., Puigdellívol, M., Bibic, L., Howell, L. A., Resel, E., Puente, N., Casarejos, M. J., Perucho, J., Botta, J., Suelves, N., Ciruela, F., Ginés, S., Galve-Roperh, I., Casadó, V., Grandes, P., Lutz, B., Monory, K., Canela, E. I., & 3 othersLluís, C., McCormick, P. J. & Guzmán, M., 2018, In: Neuropsychopharmacology. 43, p. 964–977 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

49 Citations (Scopus)

9 Downloads (Pure)
Peptide-directed binding for the discovery of modulators of α-helix-mediated protein-protein interactions: Proof-of-concept studies with the apoptosis regulator Mcl-1
Beekman, A. M., O'Connell, M. A. & Howell, L. A., 21 Aug 2017, In: Angewandte Chemie-International Edition. 56, 35, p. 10446–10450 5 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

10 Citations (Scopus)

38 Downloads (Pure)
Identification of small-molecule inhibitors of the antiapoptotic protein myeloid cell leukaemia-1 (Mcl-1)
Beekman, A. M., O'Connell, M. A. & Howell, L. A., 19 Apr 2016, In: ChemMedChem. 11, 8, p. 840–844 5 p.
Research output: Contribution to journal › Letter › peer-review

Open Access
File

13 Citations (Scopus)

26 Downloads (Pure)