Combining Click Chemistry & Peptide Synthesis to Generate Novel Inhibitors of the Anti-Apoptotic Protein Mcl-1 for the Treatment of Pancreatic Cancer.

Howell, Lesley (Principal Investigator)

School of Pharmacy

2 Article
1 Letter

3 results

2018

Singular location and signaling profile of adenosine A2A-cannabinoid CB1 receptor heteromers in the dorsal striatum
Moreno, E., Chiarlone, A., Medrano, M., Puigdellívol, M., Bibic, L., Howell, L. A., Resel, E., Puente, N., Casarejos, M. J., Perucho, J., Botta, J., Suelves, N., Ciruela, F., Ginés, S., Galve-Roperh, I., Casadó, V., Grandes, P., Lutz, B., Monory, K., Canela, E. I. & 3 others, Lluís, C., McCormick, P. J. & Guzmán, M., 2018, In: Neuropsychopharmacology. 43, p. 964–977 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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43 Citations (Scopus)

2 Downloads (Pure)
2017

Peptide-directed binding for the discovery of modulators of α-helix-mediated protein-protein interactions: Proof-of-concept studies with the apoptosis regulator Mcl-1
Beekman, A. M., O'Connell, M. A. & Howell, L. A., 21 Aug 2017, In: Angewandte Chemie International Edition. 56, 35, p. 10446–10450 5 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

7 Citations (Scopus)

29 Downloads (Pure)
2016

Identification of small-molecule inhibitors of the antiapoptotic protein myeloid cell leukaemia-1 (Mcl-1)
Beekman, A. M., O'Connell, M. A. & Howell, L. A., 19 Apr 2016, In: ChemMedChem. 11, 8, p. 840–844 5 p.
Research output: Contribution to journal › Letter › peer-review

Open Access
File

11 Citations (Scopus)

9 Downloads (Pure)