Iron-sulfur cluster-containing sensor regulators: mechanistic and structural studies of DNA-binding

Le Brun, Nick (Principal Investigator)
Crack, Jason (Co-Investigator)

Status	Active
Effective start/end date	1/01/22 → 31/12/24

Funding

Biotechnology and Biological Sciences Research Council: £482,230.00

3 Article
1 Review article

Binding of a single nitric oxide molecule is sufficient to disrupt DNA binding of the nitrosative stress regulator NsrR
Crack, J. C. & Le Brun, N., 7 Dec 2024, In: Chemical Science. 15, 45, p. 18920-18932 13 p.
Research output: Contribution to journal › Article › peer-review

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From cultivation to cancer: Formation of N-nitrosamines and other carcinogens in smokeless tobacco and their mutagenic implications
Stanfill, S. B., Hecht, S. S., Joerger, A. C., González, P. J., Maia, L. B., Rivas, M. G., Moura, J. J. G., Gupta, A. K., Le Brun, N. E., Crack, J. C., Hainaut, P., Sparacino-Watkins, C., Tyx, R. E., Pillai, S. D., Zaatari, G. S., Henley, S. J., Blount, B. C., Watson, C. H., Kaina, B. & Mehrotra, R., Dec 2023, In: Critical Reviews in Toxicology. 53, 10, p. 658-701 44 p.
Research output: Contribution to journal › Review article › peer-review

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9 Citations (Scopus)

10 Downloads (Pure)
Probing the reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator with O2 and NO: Increased O2 resistance and relative specificity for NO of the [4Fe-4S] L28H FNR cluster
Crack, J. C., Amara, P., de Rosny, E., Darnault, C., Stapleton, M. R., Green, J., Volbeda, A., Fontecilla-Camps, J. C. & Le Brun, N. E., Dec 2023, In: Inorganics. 11, 12, 18 p., 450.
Research output: Contribution to journal › Article › peer-review

Open Access
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2 Citations (Scopus)

6 Downloads (Pure)