Iron-sulfur cluster-containing sensor regulators: mechanistic and structural studies of DNA-binding

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• 2026

  Yeast [FeFe]-hydrogenase-like protein Nar1 binds a [2Fe-2S] cluster

  Braymer, J., Knauer, L., Crack, J., Oltmanns, J., Heghmanns, M., Soares, J., Le Brun, N., Schunemann, V. & Kasanmascheff, M., 21 Jan 2026, In: Chemical Science. 17, 1, p. 373-380 8 p.

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• 2025

  ArnR binds a [4Fe-4S] cluster and indirectly senses anaerobicity in Corynebacteria

  Crack, J. C., Harvey, L. R., Johnson, K. E. & Le Brun, N. E., Aug 2025, In: Metallomics. 17, 8, mfaf026.

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• Cluster occupancy- and oxidation state-dependence of Yersinia enterocolitica IscR DNA binding

  Gray, E., Gao, M., Bradley, J., Crack, J. C. & Le Brun, N. E., Nov 2025, In: Journal of Inorganic Biochemistry. 272, 113011.

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• 2024

  Binding of a single nitric oxide molecule is sufficient to disrupt DNA binding of the nitrosative stress regulator NsrR

  Crack, J. C. & Le Brun, N., 7 Dec 2024, In: Chemical Science. 15, 45, p. 18920-18932 13 p.

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  6 Citations (Scopus)

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• 2023

  Probing the reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator with O2 and NO: Increased O2 resistance and relative specificity for NO of the [4Fe-4S] L28H FNR cluster

  Crack, J. C., Amara, P., de Rosny, E., Darnault, C., Stapleton, M. R., Green, J., Volbeda, A., Fontecilla-Camps, J. C. & Le Brun, N. E., Dec 2023, In: Inorganics. 11, 12, 18 p., 450.

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• Stabilisation of the RirA [4Fe–4S] cluster results in loss of iron-sensing function

  Gray, E., Stewart, M. Y. Y., Hanwell, L., Crack, J. C., Devine, R., Stevenson, C. E. M., Volbeda, A., Johnston, A. W. B., Fontecilla-Camps, J. C., Hutchings, M. I., Todd, J. D. & Le Brun, N. E., 20 Sept 2023, In: Chemical Science. 14, 36, p. 9744-9758 15 p.

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  13 Citations (Scopus)

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