Mechanistic studies of mitochondrial ferritin, a key player in iron mediated oxidative stress response and cellular iron metabolism

Le Brun, Nick (Principal Investigator)
Bradley, Justin (Co-Investigator)
Hemmings, Andrew (Co-Investigator)

Status	Finished
Effective start/end date	1/10/17 → 30/09/20

Funding

Biotechnology and Biological Sciences Research Council: £386,428.11

Human mitochondrial ferritin exhibits highly unusual iron-O2 chemistry distinct from that of cytosolic ferritins
Bradley, J. M., Bugg, Z., Pullin, J., Moore, G. R., Svistunenko, D. A. & Le Brun, N. E., 20 May 2025, In: Nature Communications. 16, 4695.
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4 Citations (Scopus)

21 Downloads (Pure)
Observation of the assembly of the nascent mineral core at the nucleation site of human mitochondrial ferritin
Bradley, J. M., Bugg, Z., Moore, G. R., Hemmings, A. M. & Le Brun, N. E., 23 Apr 2025, In: Journal of the American Chemical Society. 147, 16, p. 13699–13710 12 p.
Research output: Contribution to journal › Article › peer-review

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18 Downloads (Pure)
Protein encapsulation within the internal cavity of a bacterioferritin
Bradley, J. M., Gray, E., Richardson, J., Moore, G. R. & Le Brun, N. E., 14 Sept 2022, In: Nanoscale. 14, 34, p. 12322-12331 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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5 Citations (Scopus)

27 Downloads (Pure)