Structural and mechanistic insights into NO sensing by iron-sulfur cluster regulators

Research output

Research output per year 2017 2018 2019 2022 2024 2024

• 14 Article

Research output per year

Research output per year

Search results

• 2024

  Binding of a single nitric oxide molecule is sufficient to disrupt DNA binding of the nitrosative stress regulator NsrR

  Crack, J. C. & Le Brun, N., 7 Dec 2024, In: Chemical Science. 15, 45, p. 18920-18932 13 p.

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• Probing the mechanism of the dedicated NO sensor [4Fe-4S] NsrR: The effect of cluster ligand environment

  Dodd, E. L. & Le Brun, N. E., Mar 2024, In: Journal of Inorganic Biochemistry. 252, 112457.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)
• 2022

  Insights into methionine S-methylation in diverse organisms

  Peng, M., Li, C-Y., Chen, X-L., Williams, B., Kang, L., Gao, Y-N., Wang, P., Wang, N., Gao, C., Zhang, S., Schoelmerich, M. C., Banfield, J. F., Miller, J. B., Le Brun, N. E., Todd, J. D. & Zhang, Y-Z., 26 May 2022, In: Nature Communications. 13, 2947.

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  13 Citations (Scopus)

  14 Downloads (Pure)

• Mechanistic insights into the key marine dimethylsulfoniopropionate synthesis enzyme DsyB/DSYB

  Li, C-Y., Crack, J. C., Newton-Payne, S., Murphy, A. R. J., Chen, X-L., Pinchbeck, B. J., Zhou, S., Williams, B. T., Peng, M., Zhang, X-H., Chen, Y., Le Brun, N. E., Todd, J. D. & Zhang, Y-Z., Jun 2022, In: mLife. 1, 2, p. 114-130 17 p.

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  8 Citations (Scopus)

  21 Downloads (Pure)

• Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors

  Rohac, R., Crack, J. C., de Rosny, E., Gigarel, O., Le Brun, N. E., Fontecilla-Camps, J. C. & Volbeda, A., 30 Jul 2022, In: Communications Biology. 5, 769.

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  9 Citations (Scopus)

  9 Downloads (Pure)

• The di-iron protein YtfE is a nitric oxide-generating nitrite reductase involved in management of nitrosative stress

  Crack, J. C., Balasiny, B. K., Bennett, S. P., Rolfe, M. D., Froes, A., MacMillan, F., Green, J., Cole, J. A. & Le Brun, N. E., 27 Apr 2022, In: Journal of the American Chemical Society. 144, 16, p. 7129–7145 17 p.

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  8 Citations (Scopus)

  10 Downloads (Pure)
• 2021

  Sensing mechanisms of iron–sulfur cluster regulatory proteins elucidated using native mass spectrometry

  Crack, J. C., Gray, E. & Le Brun, N. E., 21 Jun 2021, In: Dalton Transactions. 50, 23, p. 7887-7897 11 p.

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  13 Citations (Scopus)

  12 Downloads (Pure)
• 2020

  Interaction of the Streptomyces Wbl protein WhiD with the principal sigma factor σHrdB depends on the WhiD [4Fe-4S] cluster

  Stewart, M., Bush, M., Crack, J., Buttner, M. & Le Brun, N., 10 Jul 2020, In: Journal of Biological Chemistry. 295, 28, p. 9752-9765 14 p.

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  12 Citations (Scopus)

  28 Downloads (Pure)
• 2019

  Crystal structure of the transcription regulator RsrR reveals a [2Fe-2S] cluster coordinated by Cys, Glu and His residues

  Volbeda, A., Pellicer Martinez, M. T., Crack, J. C., Amara, P., Gigarel, O., Munnoch, J. T., Hutchings, M. I., Darnault, C., Le Brun, N. E. & Fontecilla-Camps, J. C., 13 Feb 2019, In: Journal of the American Chemical Society. 141, 6, p. 2367–2375 9 p.

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  21 Citations (Scopus)

  15 Downloads (Pure)

• Mass spectrometric identification of [4Fe-4S](NO)_x intermediates of nitric oxide sensing by regulatory iron-sulfur cluster proteins

  Crack, J. C. & Le Brun, N., 7 Mar 2019, In: Chemistry - A European Journal. 25, 14, p. 3675-3684 10 p.

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  25 Citations (Scopus)

  10 Downloads (Pure)

• Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

  Pellicer Martinez, M. T., Crack, J., Stewart, M., Bradley, J., Svistunenko, D. A., Johnston, A., Cheesman, M., Todd, J. & Le Brun, N., 17 Sep 2019, In: eLife. 8, e47804.

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  23 Citations (Scopus)

  29 Downloads (Pure)
• 2018

  Mass spectrometric detection of iron nitrosyls, sulfide oxidation and mycothiolation during nitrosylation of the NO sensor [4Fe-4S] NsrR

  Crack, J. C., Hamilton, C. J. & Le Brun, N. E., 14 Jun 2018, In: Chemical Communications. 54, 47, p. 5992-5995 4 p.

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  24 Citations (Scopus)

  18 Downloads (Pure)

• The molecular bases of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX

  Adinolfi, S., Puglisi, R., Crack, J., Iannuzzi, C., Dal Piaz, F., Konarev, P. V., Svergun, D. I., Martin, S., Le Brun, N. E. & Pastore, A., 2 Feb 2018, In: Frontiers in Molecular Biosciences. 4, 97.

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  25 Citations (Scopus)

  29 Downloads (Pure)
• 2017

  Structure of a Wbl protein and implications for NO sensing by M. tuberculosis

  Kudhair, B. K., Hounslow, A. M., Rolfe, M. D., Crack, J. C., Hunt, D. M., Buxton, R. S., Smith, L. J., Le Brun, N. E., Williamson, M. P. & Green, J., 22 Dec 2017, In: Nature Communications. 8, 2280.

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  37 Citations (Scopus)

  24 Downloads (Pure)