Vasodilatation by positive allosteric modulation of the endothelial P2X4 receptor for ATP

Fountain, Samuel (Principal Investigator)

Status	Finished
Effective start/end date	1/03/17 → 13/04/20

Funding

British Heart Foundation: £234,379.00

3 Article

Structural basis of the negative allosteric modulation of 5-BDBD at human P2X4 receptors
Bidula, S., Nadzirin, I. B., Cominetti, M., Hickey, H., Cullum, S. A., Searcey, M., Schmid, R. & Fountain, S. J., 1 Jan 2022, In: Molecular Pharmacology. 101, 1, p. 33-44 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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13 Citations (Scopus)

21 Downloads (Pure)
Neuropeptide Y facilitates P2X1 receptor-dependent vasoconstriction via Y1 receptor activation in small mesenteric arteries during sympathetic neurogenic responses
Gonzalez-Montelongo, M. & Fountain, S. J., Feb 2021, In: Vascular Pharmacology. 136, 106810.
Research output: Contribution to journal › Article › peer-review

Open Access
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11 Citations (Scopus)

22 Downloads (Pure)
Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition
Nadzirin, I. B., Fortuny‐Gomez, A., Ngum, N., Richards, D., Ali, S., Searcey, M. & Fountain, S. J., Dec 2021, In: British Journal of Pharmacology. 178, 24, p. 4859-4872 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

6 Citations (Scopus)

11 Downloads (Pure)