α-Formylation of α-substituted ketones

Jamal Hassan; Christopher J. Richards

doi:10.1055/s-0031-1290121

α-Formylation of α-substituted ketones

Jamal Hassan
, Christopher J. Richards

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The reaction of (chloromethylene)dimethylammonium chloride (generated in situ from oxalyl chloride and DMF) with α-substituted ketones in CH2Cl2, followed by workup with aqueous NaHCO3, gave β-keto aldehydes containing an α-quaternary centre (8-88% yield).

Original language	English
Pages (from-to)	239-242
Number of pages	4
Journal	Synlett
Volume	2012
Issue number	02
DOIs	https://doi.org/10.1055/s-0031-1290121
Publication status	Published - Jan 2012

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10.1055/s-0031-1290121

Cite this

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title = "α-Formylation of α-substituted ketones",

abstract = "The reaction of (chloromethylene)dimethylammonium chloride (generated in situ from oxalyl chloride and DMF) with α-substituted ketones in CH2Cl2, followed by workup with aqueous NaHCO3, gave β-keto aldehydes containing an α-quaternary centre (8-88\% yield).",

author = "Jamal Hassan and Richards, \{Christopher J.\}",

year = "2012",

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doi = "10.1055/s-0031-1290121",

language = "English",

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journal = "Synlett",

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AU - Richards, Christopher J.

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N2 - The reaction of (chloromethylene)dimethylammonium chloride (generated in situ from oxalyl chloride and DMF) with α-substituted ketones in CH2Cl2, followed by workup with aqueous NaHCO3, gave β-keto aldehydes containing an α-quaternary centre (8-88% yield).

AB - The reaction of (chloromethylene)dimethylammonium chloride (generated in situ from oxalyl chloride and DMF) with α-substituted ketones in CH2Cl2, followed by workup with aqueous NaHCO3, gave β-keto aldehydes containing an α-quaternary centre (8-88% yield).

U2 - 10.1055/s-0031-1290121

DO - 10.1055/s-0031-1290121

M3 - Article

SN - 0936-5214

VL - 2012

SP - 239

EP - 242

JO - Synlett

JF - Synlett

IS - 02

ER -