β -Lactamases- the Threat Renews

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

ß-Lactamases are the greatest single source of resistance to ß-lactam antibiotics. For over 60 years, clinicians have seen a pattern whereby useful new ß-lactam analogues are introduced but then select for new ß-lactamases that cause resistance. Thus, penicillin G was undermined by swift accumulation of staphylococcal penicillinase, ampicillin by TEM- 1 enzyme and modern oxymino cephalosporins by “extended-spectrum” ß-lactamases. Tony Fink's work contributed greatly to our understanding of the mechanisms and active site function of ß-lactamases and this knowledge now informs the search for new ß-lactams and ß-lactamase inhibitors.
Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalCurrent Protein and Peptide Science
Volume10
Issue number5
DOIs
Publication statusPublished - Oct 2009

Cite this