β1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination

Yves Benninger, Holly Colognato, Tina Thurnherr, Robin J.M. Franklin, Dino P. Leone, Suzana Atanasoski, Klaus Armin Nave, Charles Ffrench-Constant, Ueli Suter, João B. Relvas

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85 Citations (Scopus)

Abstract

Previous reports, including transplantation experiments using dominant-negative inhibition of β1-integrin signaling in oligodendrocyte progenitor cells, suggested that β1-integrin signaling is required for myelination. Here, we test this hypothesis using conditional ablation of the β1-integrin gene in oligodendroglial cells during the development of the CNS. This approach allowed us to study oligodendroglial β1-integrin signaling in the physiological environment of the CNS, circumventing the potential drawbacks of a dominant-negative approach. We found that β1-integrin signaling has a much more limited role than previously expected. Although it was involved in stage-specific oligodendrocyte cell survival, β1-integrin signaling was not required for axon ensheathment and myelination per se. We also found that, in the spinal cord, remyelination occurred normally in the absence of β1-integrin. We conclude that, although β1-integrin may still contribute to other aspects of oligodendrocyte biology, it is not essential for myelination and remyelination in the CNS.

Original languageEnglish
Pages (from-to)7665-7673
Number of pages9
JournalJournal of Neuroscience
Volume26
Issue number29
DOIs
Publication statusPublished - 19 Jul 2006

Keywords

  • CNS
  • Integrins
  • Myelin
  • Oligodendrocytes
  • Remyelination
  • Survival

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