19F NMR imaging of blood oxygenation in the brain

D. Eidelberg; G. Johnson; D. Barnes; P. S. Tofts; D. Delpy; D. Plummer; W. I. McDonald

doi:10.1002/mrm.1910060312

19F NMR imaging of blood oxygenation in the brain

D. Eidelberg, G. Johnson, D. Barnes, P. S. Tofts, D. Delpy, D. Plummer, W. I. McDonald

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Abstract

Perfluorocarbon (PFC) emulsions have been developed as oxygen carrying blood substitutes. High fluorine concentrations allow them to be used in 19F NMR imaging of blood vessels. Furthermore, 19F relaxation times in PFCs are dependent on oxygen tension (pO2) so that NMR imaging may provide a noninvasive method of measuring spatially localized pO2 values in vivo. Using these principles, we have formed 19F images and calculated pO2 maps of the cat brain.

Original language	English
Pages (from-to)	344-352
Number of pages	9
Journal	Magnetic Resonance in Medicine
Volume	6
Issue number	3
DOIs	https://doi.org/10.1002/mrm.1910060312
Publication status	Published - Mar 1988

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10.1002/mrm.1910060312

Cite this

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title = "19F NMR imaging of blood oxygenation in the brain",

abstract = "Perfluorocarbon (PFC) emulsions have been developed as oxygen carrying blood substitutes. High fluorine concentrations allow them to be used in 19F NMR imaging of blood vessels. Furthermore, 19F relaxation times in PFCs are dependent on oxygen tension (pO2) so that NMR imaging may provide a noninvasive method of measuring spatially localized pO2 values in vivo. Using these principles, we have formed 19F images and calculated pO2 maps of the cat brain.",

author = "D. Eidelberg and G. Johnson and D. Barnes and Tofts, {P. S.} and D. Delpy and D. Plummer and McDonald, {W. I.}",

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T1 - 19F NMR imaging of blood oxygenation in the brain

AU - Eidelberg, D.

AU - Johnson, G.

AU - Barnes, D.

AU - Tofts, P. S.

AU - Delpy, D.

AU - Plummer, D.

AU - McDonald, W. I.

PY - 1988/3

Y1 - 1988/3

N2 - Perfluorocarbon (PFC) emulsions have been developed as oxygen carrying blood substitutes. High fluorine concentrations allow them to be used in 19F NMR imaging of blood vessels. Furthermore, 19F relaxation times in PFCs are dependent on oxygen tension (pO2) so that NMR imaging may provide a noninvasive method of measuring spatially localized pO2 values in vivo. Using these principles, we have formed 19F images and calculated pO2 maps of the cat brain.

AB - Perfluorocarbon (PFC) emulsions have been developed as oxygen carrying blood substitutes. High fluorine concentrations allow them to be used in 19F NMR imaging of blood vessels. Furthermore, 19F relaxation times in PFCs are dependent on oxygen tension (pO2) so that NMR imaging may provide a noninvasive method of measuring spatially localized pO2 values in vivo. Using these principles, we have formed 19F images and calculated pO2 maps of the cat brain.

U2 - 10.1002/mrm.1910060312

DO - 10.1002/mrm.1910060312

M3 - Article

VL - 6

SP - 344

EP - 352

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 3

ER -