Abstract
Introduction of fluorine in the structure of pharmaceuticals has been an effective strategy for tuning their pharmacodynamic properties with more than 40 new drugs accessing the market in last 15 years. In this context 19F NMR can be viewed as a useful probe for investigating the host-guest chemistry of pharmaceuticals in nanosize drug delivery systems. Although the interest in confined crystallisation, nanosize devices and porous catalysts is gradually increasing, understanding of the complex phase behavior of organic molecules confined within nano-chambers or nano-reactors is still lacking. Using 19F MAS NMR, we achieved detailed mechanistic insight into the crystallization of flufenamic acid (FFA) in a confined environment of mesoporous silicas with different pore diameters (3.2 to 29 nm), providing a direct experimental proof of the formation of a molecular liquid-like layer in addition to the crystalline confined FFA form I.
Original language | English |
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Pages (from-to) | 9050-9054 |
Number of pages | 5 |
Journal | Angewandte Chemie-International Edition |
Volume | 128 |
Issue number | 31 |
Early online date | 7 Jun 2016 |
DOIs | |
Publication status | Published - 25 Jul 2016 |
Keywords
- Festkörper-NMR-Spektroskopie
- Flufenaminsäure
- Mesoporöses SiO2
- Nanokristalle
- Wirkstofftransport
Profiles
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Laszlo Fabian
- School of Chemistry, Pharmacy and Pharmacology - Lecturer
- Pharmaceutical Materials and Soft Matter - Member
Person: Research Group Member, Academic, Teaching & Research
-
Yaroslav Khimyak
- School of Chemistry, Pharmacy and Pharmacology - Professor in Solid-state NMR
- Pharmaceutical Materials and Soft Matter - Member
Person: Research Group Member, Academic, Teaching & Research