4D super-resolution microscopy with conventional fluorophores and single wavelength excitation in optically thick cells and tissues

David Baddeley, David Crossman, Sabrina Rossberger, Juliette E. Cheyne, Johanna M. Montgomery, Isuru D. Jayasinghe, Christoph Cremer, Mark B. Cannell, Christian Soeller

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)


Optical super-resolution imaging of fluorescently stained biological samples is rapidly becoming an important tool to investigate protein distribution at the molecular scale. It is therefore important to develop practical super-resolution methods that allow capturing the full three-dimensional nature of biological systems and also can visualize multiple protein species in the same sample.
Original languageEnglish
Article numbere20645
JournalPLoS One
Issue number5
Publication statusPublished - 31 May 2011


  • Animals
  • Cells, Cultured
  • Cyclic AMP
  • Humans
  • Microscopy, Fluorescence
  • Models, Theoretical
  • Myocytes, Cardiac
  • Rats
  • Succinimides

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