Find Research outputs

Search results

• Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A)

  Borrello, M. T., Schinor, B., Bartels, K., Benelkebir, H., Pereira, S., Al-Jamal, W. T., Douglas, L., Duriez, P. J., Packham, G., Haufe, G. & Ganesan, A., 15 May 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 10, p. 2099–2101

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  19 Citations (Scopus)

  25 Downloads (Pure)

• Total synthesis of altissimacoumarin D, a small molecule sirtuin1 activator

  Silva, A. C., Benelkebir, H., Lopes, R. S. C., Lopes, C. C. & Ganesan, A., 9 Feb 2018, In: Journal of the Brazilian Chemical Society. 29, 5, p. 1157-1161 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  5 Citations (Scopus)

  26 Downloads (Pure)

• Multitarget drugs: an epigenetic epiphany

  Ganesan, A., 20 Jun 2016, In: ChemMedChem. 11, 12, p. 1227-1241 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  74 Citations (Scopus)

  11 Downloads (Pure)

• Thirty years of HDAC inhibitors: 2020 hindsight

  Ho, T. C. S., Chan, A. H. Y. & Ganesan, A., 12 Nov 2020, In: Journal of Medicinal Chemistry. 63, 21, p. 12460–12484 25 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  428 Citations (Scopus)

  22 Downloads (Pure)

• A decade of antifungal leads from natural products: 2010-2019

  Aldholmi, M., Marchand, P., Ourliac-Garnier, I., Le Pape, P. & Ganesan, A., 12 Dec 2019, In: Pharmaceuticals. 12, 4, 182.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File
  59 Citations (Scopus)

  33 Downloads (Pure)

• Total synthesis, structural, and biological evaluation of stylissatin A and related analogs

  Shaheen, F., Jabeen, A., Ashraf, S., Nadeem-ul-Haque, M., Ali Shah, Z., Asad Ziaee, M., Dastagir, N. & Ganesan, A., Sep 2016, In: Journal of Peptide Science. 22, 9, p. 607-617 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  14 Citations (Scopus)

  23 Downloads (Pure)

• Synthesis of carboxamide-containing tranylcypromine analogues as LSD1 (KDM1A) inhibitors targeting acute myeloid leukemia

  Teresa Borrello, M., Benelkebir, H., Lee, A., Hin Tam, C., Shafat, M., Rushworth, S. A., Bowles, K. M., Douglas, L., Duriez, P. J., Bailey, S., Crabb, S. J., Packham, G. & Ganesan, A., 20 Apr 2021, In: ChemMedChem. 16, 8, p. 1316-1324 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  7 Citations (Scopus)

  15 Downloads (Pure)

• Cellular analysis of the action of epigenetics drugs and probes

  Hau, M., Zenk, F., Ganesan, A., Iovino, N. & Jung, M., Jan 2017, In: Epigenetics. 12, 5, p. 308-322 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  6 Citations (Scopus)

  17 Downloads (Pure)

• β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders

  Vaidergorn, M. M., Carneiro, Z. A., Lopes, C. D., de Albuquerque, S., Reis, F. C. C., Nikolaou, S., Mello, J. F. R., Genesi, G. L., Trossini, G. H. G., Ganesan, A. & Emery, F. S., 5 Sep 2018, In: European Journal of Medicinal Chemistry. 157, p. 657-664 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  17 Citations (Scopus)

  17 Downloads (Pure)

• Synthesis of breast cancer targeting conjugate of temporin-SHa analog and its effect on pro- and anti-apoptotic protein expression in MCF-7 cells

  Shaheen, F., Nadeem-ul-Haque, M., Ahmed, A., Simjee, S. U., Ganesan, A., Jabeen, A., Shah, Z. A. & Choudhary, M. I., Aug 2018, In: Peptides. 106, p. 68-82 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  16 Citations (Scopus)

  33 Downloads (Pure)

• New tranylcypromine derivatives containing sulfonamide motif as potent LSD1 inhibitors to target acute myeloid leukemia: design, synthesis and biological evaluation

  Liang, L., Wang, H., Du, Y., Luo, B., Meng, N., Cen, M., Huang, P., Ganesan, A. & Wen, S., Jun 2020, In: Bioorganic Chemistry. 99, 103808.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  19 Citations (Scopus)

  13 Downloads (Pure)

• Euglenatides, potent antiproliferative cyclic peptides isolated from the freshwater photosynthetic microalga Euglena gracilis

  Ganesan, A., Aldholmi, M., Ahmad, R., Carretero-Molina, D., Pérez-Victoria, I., Martín, J., Reyes, F., Genilloud, O., Gourbeyre, L., Gefflaut, T., Carlsson, H., Maklakov, A., Field, R. A., O'Neill, E., Wilkinson, B. & O'Connell, M., 7 Jun 2022, In: Angewandte Chemie-International Edition. 61, 23, e202203175.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  11 Citations (Scopus)

  18 Downloads (Pure)

• Insights into the structure-activity relationship of glycosides as positive allosteric modulators acting on P2X7 receptors

  Piyasirananda, W., Beekman, A., Ganesan, A., Bidula, S. & Stokes, L., 1 Feb 2021, In: Molecular Pharmacology. 99, 2, p. 163-174 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  9 Citations (Scopus)

  25 Downloads (Pure)

• Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines

  Maujean, T., Girard, N., Ganesan, A., Gulea, M. & Bonnet, D., 2020, In: RSC Advances. 10, 71, p. 43358-43370 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  4 Citations (Scopus)

  33 Downloads (Pure)

• Two-hit wonders: The expanding universe of multitargeting epigenetic agents

  De Lera, A. R. & Ganesan, A., Aug 2020, In: Current Opinion in Chemical Biology. 57, p. 135-154 20 p.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• Pictet-Spengler reaction using ion-exchange resin as a catalyst and support for ‘catch and release’ purification

  Izumi, M., Kido, T., Murakami, M., Nakajima, S. & Ganesan, A., 2011, In: Bioscience, Biotechnology, and Biochemistry. 75, 2, p. 391-392 2 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Solid-phase total synthesis of cherimolacyclopeptide E and discovery of more potent analogues by alanine screening

  Shaheen, F., Rizvi, T. S., Musharraf, S. G., Ganesan, A., Xiao, K., Townsend, J. B., Lam, K. S. & Choudhary, M. I., 26 Nov 2012, In: Journal of Natural Products. 75, 11, p. 1882-1887 6 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Combinational aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP)

  Bonnet, D., Margathe, J-F., Radford, S., Pflimlin, E., Riche, S., Doman, P., Hibert, M. & Ganesan, A., 2012, In: ACS Combinatorial Science. 14, 5, p. 323-334 12 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Editorial overview: Epigenetics equals chemical biology

  Kawamura, A. & Ganesan, A., Aug 2020, In: Current Opinion in Chemical Biology. 57, p. A1-A4 4 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Citation (Scopus)

• A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

  Iijima, Y., Munakata, A., Shin-ya, K., Ganesan, A., Doi, T. & Takahashi, T., 17 Jun 2009, In: Tetrahedron Letters. 50, 24, p. 2970-2972 3 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis

  Conforti, F., Davies, E. R., Calderwood, C. J., Thatcher, T. H., Jones, M. G., Smart, D. E., Mahajan, S., Alzetani, A., Havelock, T., Maher, T. M., Molyneaux, P. L., Thorley, A. J., Tetley, T. D., Warner, J. A. ., Packham, G., Ganesan, A., Skipp, P. J., Marshall, B. J., Richeldi, L., Sime, P. J., & 2 othersO’reilly, K. M. A. & Davies, D. E., 14 Apr 2017, In: Oncotarget. 8, p. 48737-48754 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  42 Citations (Scopus)

  23 Downloads (Pure)

• LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models

  Regufe da Mota, S., Bailey, S., Strivens, R. A., Hayden, A. L., Douglas, L. R., Duriez, P. J., Borrello, M. T., Benelkebir, H., Ganesan, A., Packham, G. & Crabb, S. J., 9 May 2018, In: Cancer Cell International. 18, 71.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  19 Citations (Scopus)

  22 Downloads (Pure)

• Depsipeptides and their Therapeutic Use

  Packham, G., Ganesan, A. & Cecil, A. R. L., 2008, Patent No. WO2008062232

  Research output: Patent

• Fk 228 derivates as hdac inhibitors

  Ganesan, A., Packham, G., Yurek-George, A. & Cecil, A. R. L., 2005, Patent No. WO-2006129105-A1

  Research output: Patent

• Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

  Wen, S., Carey, K. L., Nakao, Y., Fusetani, N., Packham, G. & Ganesan, A., 1 Mar 2007, In: Organic Letters. 9, 6, p. 1105-1108 4 p.

  Research output: Contribution to journal › Article › peer-review
  55 Citations (Scopus)