A biodegradable multiblock co-polymer derived from an alpha,omega-bis(methylamino)peptide and an alpha,omega-bis(oxiranylmethyl)poly(ethylene glycol)

Susan E. Matthews, Colin W. Pouton, Michael D. Threadgill

    Research output: Contribution to journal › Article › peer-review

    13 Citations (Scopus)

    Abstract

    A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with alpha,omega-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M-w 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme. (C) 2000 Elsevier Science B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)129-139
    Number of pages11
    JournalJournal of Controlled Release
    Volume67
    Issue number2-3
    DOIs
    Publication statusPublished - 2000

    Keywords

    • ETHERS
    • biodegradable
    • peptide
    • GlyPheLeuGly
    • PRODRUGS
    • COPOLYMERS
    • DRUG
    • DERIVATIVES
    • cathepsin B
    • polyethylene glycol
    • ENZYMATICALLY DEGRADABLE BONDS
    • RELEASE
    • retro-inverso
    • CARRIERS

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