A biodegradable multiblock co-polymer derived from an alpha,omega-bis(methylamino)peptide and an alpha,omega-bis(oxiranylmethyl)poly(ethylene glycol)

S. E. Matthews, C. W. Pouton, M. D. Threadgill

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with alpha,omega-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M-w 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme. (C) 2000 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalJournal of Controlled Release
Volume67
Issue number2-3
Publication statusPublished - 2000

Keywords

  • ETHERS
  • biodegradable
  • peptide
  • GlyPheLeuGly
  • PRODRUGS
  • COPOLYMERS
  • DRUG
  • DERIVATIVES
  • cathepsin B
  • polyethylene glycol
  • ENZYMATICALLY DEGRADABLE BONDS
  • RELEASE
  • retro-inverso
  • CARRIERS

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