A C-2-symmetric metallocene-pyrrolidinopyridine nucleophilic catalyst for asymmetric synthesis

H. V. Nguyen; M. Motevalli; C. J. Richards

doi:10.1055/s-2007-970764

A C-2-symmetric metallocene-pyrrolidinopyridine nucleophilic catalyst for asymmetric synthesis

H. V. Nguyen, M. Motevalli, C. J. Richards

Chemistry of Materials and Catalysis

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A C-2 -symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2',5'-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity factors (s) of up to 6.

Original language	English
Pages (from-to)	725-728
Number of pages	4
Journal	Synlett
Issue number	5
DOIs	https://doi.org/10.1055/s-2007-970764
Publication status	Published - 2007

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10.1055/s-2007-970764

Cite this

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title = "A C-2-symmetric metallocene-pyrrolidinopyridine nucleophilic catalyst for asymmetric synthesis",

abstract = "A C-2 -symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2',5'-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity factors (s) of up to 6.",

author = "Nguyen, {H. V.} and M. Motevalli and Richards, {C. J.}",

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journal = "Synlett",

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AU - Nguyen, H. V.

AU - Motevalli, M.

AU - Richards, C. J.

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PY - 2007

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N2 - A C-2 -symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2',5'-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity factors (s) of up to 6.

AB - A C-2 -symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2',5'-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity factors (s) of up to 6.

U2 - 10.1055/s-2007-970764

DO - 10.1055/s-2007-970764

M3 - Article

SN - 0936-5214

SP - 725

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JO - Synlett

JF - Synlett

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