A comparison of clinicopathological features and molecular markers in British and Nigerian women with breast cancer

Isaac D. Gukas; Anne C. Girling; Barnabas M. Mandong; Wendy Prime; Barbara A. Jennings; Samuel J. Leinster

doi:10.4137/CMO.S474

A comparison of clinicopathological features and molecular markers in British and Nigerian women with breast cancer

Isaac D. Gukas, Anne C. Girling, Barnabas M. Mandong, Wendy Prime, Barbara A. Jennings, Samuel J. Leinster

Research output: Contribution to journal › Article

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Abstract

Background: Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study's aim was to look for evidence of differences in tumour biology between the two cohorts.

Methods: This study compared the stage, grade and pathological expression of five immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks.

Results: There were significant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no significant differences were observed for tumour grade.

Conclusion: There was a significantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely influence prognosis between Nigerian and British women with breast cancer.

Original language	English
Pages (from-to)	347-351
Number of pages	5
Journal	Clinical Medicine: Oncology
Volume	2
DOIs	https://doi.org/10.4137/CMO.S474
Publication status	Published - 2008

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Cite this

@article{132decb74eb64989986abc81e57489ce,

title = "A comparison of clinicopathological features and molecular markers in British and Nigerian women with breast cancer",

abstract = "Background: Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study's aim was to look for evidence of differences in tumour biology between the two cohorts. Methods: This study compared the stage, grade and pathological expression of five immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks. Results: There were significant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no significant differences were observed for tumour grade. Conclusion: There was a significantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely influence prognosis between Nigerian and British women with breast cancer. ",

author = "Gukas, {Isaac D.} and Girling, {Anne C.} and Mandong, {Barnabas M.} and Wendy Prime and Jennings, {Barbara A.} and Leinster, {Samuel J.}",

year = "2008",

doi = "10.4137/CMO.S474",

language = "English",

volume = "2",

pages = "347--351",

journal = "Clinical Medicine: Oncology",

issn = "1177-9314",

publisher = "Libertas Academica Ltd.",

}

TY - JOUR

T1 - A comparison of clinicopathological features and molecular markers in British and Nigerian women with breast cancer

AU - Gukas, Isaac D.

AU - Girling, Anne C.

AU - Mandong, Barnabas M.

AU - Prime, Wendy

AU - Jennings, Barbara A.

AU - Leinster, Samuel J.

PY - 2008

Y1 - 2008

N2 - Background: Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study's aim was to look for evidence of differences in tumour biology between the two cohorts. Methods: This study compared the stage, grade and pathological expression of five immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks. Results: There were significant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no significant differences were observed for tumour grade. Conclusion: There was a significantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely influence prognosis between Nigerian and British women with breast cancer.

AB - Background: Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study's aim was to look for evidence of differences in tumour biology between the two cohorts. Methods: This study compared the stage, grade and pathological expression of five immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks. Results: There were significant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no significant differences were observed for tumour grade. Conclusion: There was a significantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely influence prognosis between Nigerian and British women with breast cancer.

U2 - 10.4137/CMO.S474

DO - 10.4137/CMO.S474

M3 - Article

SN - 1177-9314

VL - 2

SP - 347

EP - 351

JO - Clinical Medicine: Oncology

JF - Clinical Medicine: Oncology

ER -