A comparison of the central nervous system effects of caffeine and theophylline in elderly subjects

G Yu, V Maskray, S H Jackson, C G Swift, B Tiplady, Vivienne Maskrey

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38 Citations (Scopus)


1. The effects of oral administration of 250 mg caffeine or theophylline and placebo on subjective ratings and psychological test performance were studied in a double-blind crossover experiment in 20 healthy elderly subjects. 2. Performance on the continuous attention task showed a significant improvement compared with placebo with both active treatments. Performance with caffeine was significantly better than with theophylline. Mean error index scores (normalised AUCs) were: placebo--0.130; caffeine--0.083; theophylline--0.093. No other objective measure shows significant treatment effects. 3. Subjective ratings showed that subjects felt significantly more alert on caffeine than on either theophylline or placebo. Subjects also rated themselves as more energetic and interested on caffeine than on placebo. 4. Plasma concentrations of caffeine were lower than those of theophylline (mean 5.76 and 8.72 mg l-1 respectively at 2 h post-drug. 5. These results suggest that caffeine is a more potent CNS stimulant than theophylline.
Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalBritish Journal of Clinical Pharmacology
Issue number3
Publication statusPublished - Sep 1991


  • Aged
  • Caffeine
  • Central Nervous System
  • Double-Blind Method
  • Humans
  • Middle Aged
  • Neuropsychological Tests
  • Psychomotor Performance
  • Reference Values
  • Theophylline

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