A conserved module regulates receptor kinase signalling in immunity and development

Thomas A. DeFalco, Pauline Anne, Sean R. James, Andrew C. Willoughby, Florian Schwanke, Oliver Johanndrees, Yasmine Genolet, Paul Derbyshire, Qian Wang, Surbhi Rana, Anne-Marie Pullen, Frank L.H. Menke, Cyril Zipfel, Christian S. Hardtke, Zachary L. Nimchuk

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signalling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signalling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development uses a similar regulatory module. In the absence of ligand, signalling is dampened through association with specific type-2C protein phosphatases. Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting receptor signalling. Our work reveals a regulatory circuit shared between immune and developmental receptor signalling, which may have broader important implications for plant receptor kinase-mediated signalling in general.

Original languageEnglish
Pages (from-to)356-365
Number of pages10
JournalNature Plants
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 2022
Externally publishedYes

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