A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators

Petros G. Tsoungas; Mark Searcey

doi:10.1016/S0040-4039(01)01302-8

A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators

Petros G. Tsoungas, Mark Searcey

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted phthalazine. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	6589-6592
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	37
DOIs	https://doi.org/10.1016/S0040-4039(01)01302-8
Publication status	Published - 2001

Keywords

AGENTS
NITRITE
CONVERSION
ARYL HALIDES

Access to Document

10.1016/S0040-4039(01)01302-8

Cite this

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title = "A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators",

abstract = "2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted phthalazine. (C) 2001 Elsevier Science Ltd. All rights reserved.",

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AU - Tsoungas, Petros G.

AU - Searcey, Mark

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N2 - 2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted phthalazine. (C) 2001 Elsevier Science Ltd. All rights reserved.

AB - 2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted phthalazine. (C) 2001 Elsevier Science Ltd. All rights reserved.

KW - AGENTS

KW - NITRITE

KW - CONVERSION

KW - ARYL HALIDES

U2 - 10.1016/S0040-4039(01)01302-8

DO - 10.1016/S0040-4039(01)01302-8

M3 - Article

VL - 42

SP - 6589

EP - 6592

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 37

ER -