A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators

Petros G. Tsoungas, Mark Searcey

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted phthalazine. (C) 2001 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)6589-6592
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number37
DOIs
Publication statusPublished - 2001

Keywords

  • AGENTS
  • NITRITE
  • CONVERSION
  • ARYL HALIDES

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