A convenient and versatile method for the synthesis of protected guanidines

Zhao-Xia Guo, Andrew N. Cammidge, David C. Horwell

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Aromatic, aliphatic and sterically hindered amines react smoothly with commercially available N,N'-bis-BOC-S-methylisothiourea 2 in the presence of mercury chloride to give the protected guanidine in good yield. It is particularly noteworthy that 2 can also be employed in a straightforward, two-step synthesis of monoaryl internal guanidines.
Original languageEnglish
Pages (from-to)2933-2943
Number of pages11
JournalSynthetic Communications
Issue number16
Publication statusPublished - 2000

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