A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

Michael Winn; Abhijeet D. Roy; Sabine Grüschow; Raj S. Parameswaran; Rebecca J. M. Goss

doi:10.1016/j.bmcl.2008.07.053

A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

Michael Winn, Abhijeet D. Roy, Sabine Grüschow, Raj S. Parameswaran, Rebecca J. M. Goss

School of Chemistry

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity.

Original language	English
Pages (from-to)	4508-4510
Number of pages	3
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	18
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2008.07.053
Publication status	Published - 2008

Keywords

DESIGN
STATE
GENETIC-CODE
preparation
TRYPTOPHAN SYNTHASE
halotryptophan
aminotryptophan
biotransformation
tryptophan synthase
ANTIBIOTICS

Access to Document

10.1016/j.bmcl.2008.07.053

Cite this

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title = "A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan",

abstract = "A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity.",

keywords = "DESIGN, STATE, GENETIC-CODE, preparation, TRYPTOPHAN SYNTHASE, halotryptophan, aminotryptophan, biotransformation, tryptophan synthase, ANTIBIOTICS",

author = "Michael Winn and Roy, {Abhijeet D.} and Sabine Gr{\"u}schow and Parameswaran, {Raj S.} and Goss, {Rebecca J. M.}",

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language = "English",

volume = "18",

pages = "4508--4510",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

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T1 - A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

AU - Winn, Michael

AU - Roy, Abhijeet D.

AU - Grüschow, Sabine

AU - Parameswaran, Raj S.

AU - Goss, Rebecca J. M.

PY - 2008

Y1 - 2008

N2 - A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity.

AB - A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity.

KW - DESIGN

KW - STATE

KW - GENETIC-CODE

KW - preparation

KW - TRYPTOPHAN SYNTHASE

KW - halotryptophan

KW - aminotryptophan

KW - biotransformation

KW - tryptophan synthase

KW - ANTIBIOTICS

U2 - 10.1016/j.bmcl.2008.07.053

DO - 10.1016/j.bmcl.2008.07.053

M3 - Article

VL - 18

SP - 4508

EP - 4510

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 16

ER -