A cost-effective combination of Rose Bengal and off-the-shelf cationic polystyrene for the photodynamic inactivation of Pseudomonas aeruginosa

Carla Arnau del Valle, Vanesa Perez-Laguna, Ignacio Munoz Resta, Raquel Gavara, Carles Felip-Leon, Juan F. Miravet, Antonio Rezusta, Francisco Galindo

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Two new photoactive materials have been prepared, characterized and tested against Pseudomonas aeruginosa bacteria (planktonic suspension). The synthesis of the polymeric photosensitizers can be made at a multigram scale, in few minutes, starting from inexpensive and readily available materials, such as Rose Bengal (photosensitizer) and ion exchange resins Amberlite® IRA 900 (macroporous) or IRA 400 (gel-type) as cationic polystyrene supports. The most notable feature of these systems is their notable bactericidal activity in the dark (4–5 log 10 CFU/mL reduction of the population of P. aeruginosa) which becomes enhanced upon irradiation with visible light (to reach a total reduction of 8 log 10 CFU/mL for the macroporous polymer at a fluence of 120 J/cm 2 using green light of 515 nm).

Original languageEnglish
Article number111302
Number of pages7
JournalMaterials Science and Engineering: C
Early online date24 Jul 2020
Publication statusPublished - Dec 2020


  • Antimicrobial photodynamic inactivation
  • Bactericidal materials
  • Photosensitizers
  • Rose Bengal
  • Singlet oxygen

Cite this