A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment

Ping Wu; Brian A Walker; Daniel Brewer; Walter M Gregory; John Ashcroft; Fiona M Ross; Graham H Jackson; Anthony J Child; Faith E Davies; Gareth J Morgan

doi:10.1158/1078-0432.CCR-11-0994

A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment

Ping Wu, Brian A Walker, Daniel Brewer, Walter M Gregory, John Ashcroft, Fiona M Ross, Graham H Jackson, Anthony J Child, Faith E Davies, Gareth J Morgan

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Myeloma bone disease impairs quality of life and is associated with impaired survival. Even with effective bisphosphonate treatment, a significant proportion of patients still develop skeletal-related events (SRE). Identifying such patients at presentation would allow treatment modification.

Original language	English
Pages (from-to)	6347-55
Number of pages	9
Journal	Clinical Cancer Research
Volume	17
Issue number	19
DOIs	https://doi.org/10.1158/1078-0432.CCR-11-0994
Publication status	Published - 1 Oct 2011

Keywords

Aged
Bone Diseases
Diphosphonates
Gene Expression Profiling
Humans
Models, Theoretical
Multiple Myeloma
Predictive Value of Tests
Risk
Validation Studies as Topic

Access to Document

10.1158/1078-0432.CCR-11-0994

Cite this

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title = "A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment",

abstract = "Myeloma bone disease impairs quality of life and is associated with impaired survival. Even with effective bisphosphonate treatment, a significant proportion of patients still develop skeletal-related events (SRE). Identifying such patients at presentation would allow treatment modification.",

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A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment. / Wu, Ping; Walker, Brian A; Brewer, Daniel; Gregory, Walter M; Ashcroft, John; Ross, Fiona M; Jackson, Graham H; Child, Anthony J; Davies, Faith E; Morgan, Gareth J.

In: Clinical Cancer Research, Vol. 17, No. 19, 01.10.2011, p. 6347-55.

Research output: Contribution to journal › Article › peer-review

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KW - Predictive Value of Tests

KW - Risk

KW - Validation Studies as Topic

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