A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment

Ping Wu, Brian A Walker, Daniel Brewer, Walter M Gregory, John Ashcroft, Fiona M Ross, Graham H Jackson, Anthony J Child, Faith E Davies, Gareth J Morgan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Myeloma bone disease impairs quality of life and is associated with impaired survival. Even with effective bisphosphonate treatment, a significant proportion of patients still develop skeletal-related events (SRE). Identifying such patients at presentation would allow treatment modification.
Original languageEnglish
Pages (from-to)6347-55
Number of pages9
JournalClinical Cancer Research
Volume17
Issue number19
DOIs
Publication statusPublished - 1 Oct 2011

Keywords

  • Aged
  • Bone Diseases
  • Diphosphonates
  • Gene Expression Profiling
  • Humans
  • Models, Theoretical
  • Multiple Myeloma
  • Predictive Value of Tests
  • Risk
  • Validation Studies as Topic

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