A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment

Ping Wu; Brian A Walker; Daniel Brewer; Walter M Gregory; John Ashcroft; Fiona M Ross; Graham H Jackson; Anthony J Child; Faith E Davies; Gareth J Morgan

doi:10.1158/1078-0432.CCR-11-0994

A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment

Ping Wu, Brian A Walker, Daniel Brewer, Walter M Gregory, John Ashcroft, Fiona M Ross, Graham H Jackson, Anthony J Child, Faith E Davies, Gareth J Morgan

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Myeloma bone disease impairs quality of life and is associated with impaired survival. Even with effective bisphosphonate treatment, a significant proportion of patients still develop skeletal-related events (SRE). Identifying such patients at presentation would allow treatment modification.

Original language	English
Pages (from-to)	6347-55
Number of pages	9
Journal	Clinical Cancer Research
Volume	17
Issue number	19
DOIs	https://doi.org/10.1158/1078-0432.CCR-11-0994
Publication status	Published - 1 Oct 2011

Keywords

Aged
Bone Diseases
Diphosphonates
Gene Expression Profiling
Humans
Models, Theoretical
Multiple Myeloma
Predictive Value of Tests
Risk
Validation Studies as Topic

Access to Document

10.1158/1078-0432.CCR-11-0994

Cite this

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title = "A gene expression-based predictor for myeloma patients at high risk of developing bone disease on bisphosphonate treatment",

abstract = "Myeloma bone disease impairs quality of life and is associated with impaired survival. Even with effective bisphosphonate treatment, a significant proportion of patients still develop skeletal-related events (SRE). Identifying such patients at presentation would allow treatment modification.",

keywords = "Aged, Bone Diseases, Diphosphonates, Gene Expression Profiling, Humans, Models, Theoretical, Multiple Myeloma, Predictive Value of Tests, Risk, Validation Studies as Topic",

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AU - Walker, Brian A

AU - Brewer, Daniel

AU - Gregory, Walter M

AU - Ashcroft, John

AU - Ross, Fiona M

AU - Jackson, Graham H

AU - Child, Anthony J

AU - Davies, Faith E

AU - Morgan, Gareth J

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KW - Bone Diseases

KW - Diphosphonates

KW - Gene Expression Profiling

KW - Humans

KW - Models, Theoretical

KW - Multiple Myeloma

KW - Predictive Value of Tests

KW - Risk

KW - Validation Studies as Topic

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