A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis

S. Snelling, R. Rout, R. Davidson, I. Clark, A. Carr, P.A. Hulley, A.J. Price

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Objective: To identify osteoarthritis (OA) relevant genes and pathways in damaged and undamaged cartilage isolated from the knees of patients with anteromedial gonarthrosis (AMG) - a specific form of knee OA. Design: Cartilage was obtained from nine patients undergoing unicompartmental knee replacement (UKR) for AMG. AMG provides a spatial representation of OA progression; showing a reproducible and histologically validated pattern of cartilage destruction such that damaged and undamaged cartilage from within the same knee can be consistently isolated and examined. Gene expression was analysed by microarray and validated using real-time PCR. Results: Damaged and undamaged cartilage showed distinct gene expression profiles. 754 genes showed significant up- or down-regulation (non-False discovery rate (FDR) P
Original languageEnglish
Pages (from-to)334-343
Number of pages10
JournalOsteoarthritis and Cartilage
Volume22
Issue number2
DOIs
Publication statusPublished - 1 Feb 2014

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