Abstract
Objective: To identify osteoarthritis (OA) relevant genes and pathways in damaged and undamaged cartilage isolated from the knees of patients with anteromedial gonarthrosis (AMG) - a specific form of knee OA. Design: Cartilage was obtained from nine patients undergoing unicompartmental knee replacement (UKR) for AMG. AMG provides a spatial representation of OA progression; showing a reproducible and histologically validated pattern of cartilage destruction such that damaged and undamaged cartilage from within the same knee can be consistently isolated and examined. Gene expression was analysed by microarray and validated using real-time PCR. Results: Damaged and undamaged cartilage showed distinct gene expression profiles. 754 genes showed significant up- or down-regulation (non-False discovery rate (FDR) P
Original language | English |
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Pages (from-to) | 334-343 |
Number of pages | 10 |
Journal | Osteoarthritis and Cartilage |
Volume | 22 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2014 |
Profiles
-
Ian Clark
- School of Biological Sciences - Professor of Musculoskeletal Biology
- Musculoskeletal Medicine - Member
- Nutrition and Preventive Medicine - Member
- HealthUEA - Academic Chair
Person: Research Group Member, Academic, Teaching & Research