A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

John Gubbay, Jérôme Collignon, Peter Koopman, Blanche Capel, Androulla Economou, Andrea Munsterberg, Nigel Vivian, Peter Goodfellow, Robin Lovell-Badge

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Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.
Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalNature
Volume346
Issue number6281
DOIs
Publication statusPublished - 19 Jul 1990

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