A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

John Gubbay; Jérôme Collignon; Peter Koopman; Blanche Capel; Androulla Economou; Andrea Munsterberg; Nigel Vivian; Peter Goodfellow; Robin Lovell-Badge

doi:10.1038/346245a0

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

John Gubbay, Jérôme Collignon, Peter Koopman, Blanche Capel, Androulla Economou, Andrea Munsterberg, Nigel Vivian, Peter Goodfellow, Robin Lovell-Badge

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Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

Original language	English
Pages (from-to)	245-250
Number of pages	6
Journal	Nature
Volume	346
Issue number	6281
DOIs	https://doi.org/10.1038/346245a0
Publication status	Published - 19 Jul 1990

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10.1038/346245a0

Cite this

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abstract = "A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.",

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AU - Koopman, Peter

AU - Capel, Blanche

AU - Economou, Androulla

AU - Munsterberg, Andrea

AU - Vivian, Nigel

AU - Goodfellow, Peter

AU - Lovell-Badge, Robin

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AB - A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

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