A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population

N J Prescott; S A Fisher; C Onnie; R Pattni; S Steer; J Sanderson; A Forbes; C M Lewis; C G Mathew

doi:10.1111/j.1399-0039.2005.00494.x

A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population

N J Prescott, S A Fisher, C Onnie, R Pattni, S Steer, J Sanderson, A Forbes, C M Lewis, C G Mathew

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

A single-nucleotide polymorphism (C1858T) causing an amino acid substitution (R620W) in the lymphoid protein tyrosine phosphatase gene PTPN22 has been implicated in type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, juvenile idiopathic arthritis and Hashimoto's thyroiditis, thus revealing a general role for this gene in autoimmune disease. We investigated the association of the C1858T variant in an additional autoimmune disease population by performing a case-control study of 514 British individuals with inflammatory bowel disease (IBD) [294 with Crohn's disease (CD) and 220 with ulcerative colitis (UC)] and 374 normal controls. No significant differences in genotype or allele frequencies were observed between IBD, CD or UC and controls, indicating that PTPN22 does not influence risk of IBD.

Original language	English
Pages (from-to)	318-320
Number of pages	3
Journal	Tissue Antigens
Volume	66
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-0039.2005.00494.x
Publication status	Published - Oct 2005

Keywords

Amino Acid Substitution
Autoimmune Diseases
Case-Control Studies
Colitis, Ulcerative
Crohn Disease
Genetic Predisposition to Disease
Genotype
Great Britain
Polymorphism, Single Nucleotide
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Protein Tyrosine Phosphatases
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1399-0039.2005.00494.x

Cite this

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title = "A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population",

abstract = "A single-nucleotide polymorphism (C1858T) causing an amino acid substitution (R620W) in the lymphoid protein tyrosine phosphatase gene PTPN22 has been implicated in type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, juvenile idiopathic arthritis and Hashimoto's thyroiditis, thus revealing a general role for this gene in autoimmune disease. We investigated the association of the C1858T variant in an additional autoimmune disease population by performing a case-control study of 514 British individuals with inflammatory bowel disease (IBD) [294 with Crohn's disease (CD) and 220 with ulcerative colitis (UC)] and 374 normal controls. No significant differences in genotype or allele frequencies were observed between IBD, CD or UC and controls, indicating that PTPN22 does not influence risk of IBD.",

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author = "Prescott, {N J} and Fisher, {S A} and C Onnie and R Pattni and S Steer and J Sanderson and A Forbes and Lewis, {C M} and Mathew, {C G}",

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T1 - A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population

AU - Prescott, N J

AU - Fisher, S A

AU - Onnie, C

AU - Pattni, R

AU - Steer, S

AU - Sanderson, J

AU - Forbes, A

AU - Lewis, C M

AU - Mathew, C G

PY - 2005/10

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N2 - A single-nucleotide polymorphism (C1858T) causing an amino acid substitution (R620W) in the lymphoid protein tyrosine phosphatase gene PTPN22 has been implicated in type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, juvenile idiopathic arthritis and Hashimoto's thyroiditis, thus revealing a general role for this gene in autoimmune disease. We investigated the association of the C1858T variant in an additional autoimmune disease population by performing a case-control study of 514 British individuals with inflammatory bowel disease (IBD) [294 with Crohn's disease (CD) and 220 with ulcerative colitis (UC)] and 374 normal controls. No significant differences in genotype or allele frequencies were observed between IBD, CD or UC and controls, indicating that PTPN22 does not influence risk of IBD.

AB - A single-nucleotide polymorphism (C1858T) causing an amino acid substitution (R620W) in the lymphoid protein tyrosine phosphatase gene PTPN22 has been implicated in type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, juvenile idiopathic arthritis and Hashimoto's thyroiditis, thus revealing a general role for this gene in autoimmune disease. We investigated the association of the C1858T variant in an additional autoimmune disease population by performing a case-control study of 514 British individuals with inflammatory bowel disease (IBD) [294 with Crohn's disease (CD) and 220 with ulcerative colitis (UC)] and 374 normal controls. No significant differences in genotype or allele frequencies were observed between IBD, CD or UC and controls, indicating that PTPN22 does not influence risk of IBD.

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KW - Case-Control Studies

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Great Britain

KW - Polymorphism, Single Nucleotide

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KW - Protein Tyrosine Phosphatase, Non-Receptor Type 22

KW - Protein Tyrosine Phosphatases

KW - Risk Factors

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DO - 10.1111/j.1399-0039.2005.00494.x

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JF - Tissue Antigens

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