A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries: a randomised controlled trial

Samford Wong, Ali Jamous, Jean O'Driscoll, Ravi Sekhar, Mike Weldon, Chi Y Yau, Shashivadan P Hirani, George Grimble, Alastair Forbes

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Certain probiotics may prevent the development of antibiotic-associated diarrhoea (AAD) and Clostridium difficile-associated diarrhoea (CDAD), but their effectiveness depends on both strain and dose. There are few data on nutritional interventions to control AAD/CDAD in the spinal cord injury (SCI) population. The present study aimed to assess (1) the efficacy of consuming a commercially produced probiotic containing at least 6·5 × 10⁹ live Lactobacillus casei Shirota (LcS) in reducing the incidence of AAD/CDAD, and (2) whether undernutrition and proton pump inhibitors (PPI) are risk factors for AAD/CDAD. A total of 164 SCI patients (50·1 (sd 17·8) years) with a requirement for antibiotics (median 21 d, range 5-366) were randomly allocated to receive LcS (n 76) or no probiotic (n 82). LcS was given once daily for the duration of the antibiotic course and continued for 7 days thereafter. Nutritional risk was assessed by the Spinal Nutrition Screening Tool. The LcS group had a significantly lower incidence of AAD (17·1 v. 54·9%, P
Original languageEnglish
Pages (from-to)672-8
Number of pages7
JournalBritish Journal of Nutrition
Issue number4
Publication statusPublished - Feb 2014


  • Anti-Bacterial Agents
  • Appetite
  • Clostridium difficile
  • Diarrhea
  • Double-Blind Method
  • Energy Intake
  • Female
  • Hospitalization
  • Humans
  • Incidence
  • Lactobacillus casei
  • Logistic Models
  • Male
  • Malnutrition
  • Meals
  • Middle Aged
  • Multivariate Analysis
  • Nutritional Status
  • Probiotics
  • Proton Pump Inhibitors
  • Risk Factors
  • Spinal Cord Injuries
  • Treatment Outcome

Cite this