A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries: a randomised controlled trial

Samford Wong; Ali Jamous; Jean O'Driscoll; Ravi Sekhar; Mike Weldon; Chi Y Yau; Shashivadan P Hirani; George Grimble; Alastair Forbes

doi:10.1017/S0007114513002973

A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries: a randomised controlled trial

Samford Wong, Ali Jamous, Jean O'Driscoll, Ravi Sekhar, Mike Weldon, Chi Y Yau, Shashivadan P Hirani, George Grimble, Alastair Forbes

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Certain probiotics may prevent the development of antibiotic-associated diarrhoea (AAD) and Clostridium difficile-associated diarrhoea (CDAD), but their effectiveness depends on both strain and dose. There are few data on nutritional interventions to control AAD/CDAD in the spinal cord injury (SCI) population. The present study aimed to assess (1) the efficacy of consuming a commercially produced probiotic containing at least 6·5 × 10⁹ live Lactobacillus casei Shirota (LcS) in reducing the incidence of AAD/CDAD, and (2) whether undernutrition and proton pump inhibitors (PPI) are risk factors for AAD/CDAD. A total of 164 SCI patients (50·1 (sd 17·8) years) with a requirement for antibiotics (median 21 d, range 5-366) were randomly allocated to receive LcS (n 76) or no probiotic (n 82). LcS was given once daily for the duration of the antibiotic course and continued for 7 days thereafter. Nutritional risk was assessed by the Spinal Nutrition Screening Tool. The LcS group had a significantly lower incidence of AAD (17·1 v. 54·9%, P

Original language	English
Pages (from-to)	672-8
Number of pages	7
Journal	British Journal of Nutrition
Volume	111
Issue number	4
DOIs	https://doi.org/10.1017/S0007114513002973
Publication status	Published - Feb 2014

Keywords

Anti-Bacterial Agents
Appetite
Clostridium difficile
Diarrhea
Double-Blind Method
Energy Intake
Female
Hospitalization
Humans
Incidence
Lactobacillus casei
Logistic Models
Male
Malnutrition
Meals
Middle Aged
Multivariate Analysis
Nutritional Status
Probiotics
Proton Pump Inhibitors
Risk Factors
Spinal Cord Injuries
Treatment Outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1017/S0007114513002973

Cite this

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title = "A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries: a randomised controlled trial",

abstract = "Certain probiotics may prevent the development of antibiotic-associated diarrhoea (AAD) and Clostridium difficile-associated diarrhoea (CDAD), but their effectiveness depends on both strain and dose. There are few data on nutritional interventions to control AAD/CDAD in the spinal cord injury (SCI) population. The present study aimed to assess (1) the efficacy of consuming a commercially produced probiotic containing at least 6·5 × 10⁹ live Lactobacillus casei Shirota (LcS) in reducing the incidence of AAD/CDAD, and (2) whether undernutrition and proton pump inhibitors (PPI) are risk factors for AAD/CDAD. A total of 164 SCI patients (50·1 (sd 17·8) years) with a requirement for antibiotics (median 21 d, range 5-366) were randomly allocated to receive LcS (n 76) or no probiotic (n 82). LcS was given once daily for the duration of the antibiotic course and continued for 7 days thereafter. Nutritional risk was assessed by the Spinal Nutrition Screening Tool. The LcS group had a significantly lower incidence of AAD (17·1 v. 54·9%, P",

keywords = "Anti-Bacterial Agents, Appetite, Clostridium difficile, Diarrhea, Double-Blind Method, Energy Intake, Female, Hospitalization, Humans, Incidence, Lactobacillus casei, Logistic Models, Male, Malnutrition, Meals, Middle Aged, Multivariate Analysis, Nutritional Status, Probiotics, Proton Pump Inhibitors, Risk Factors, Spinal Cord Injuries, Treatment Outcome",

author = "Samford Wong and Ali Jamous and Jean O'Driscoll and Ravi Sekhar and Mike Weldon and Yau, {Chi Y} and Hirani, {Shashivadan P} and George Grimble and Alastair Forbes",

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doi = "10.1017/S0007114513002973",

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T1 - A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries

T2 - a randomised controlled trial

AU - Wong, Samford

AU - Jamous, Ali

AU - O'Driscoll, Jean

AU - Sekhar, Ravi

AU - Weldon, Mike

AU - Yau, Chi Y

AU - Hirani, Shashivadan P

AU - Grimble, George

AU - Forbes, Alastair

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N2 - Certain probiotics may prevent the development of antibiotic-associated diarrhoea (AAD) and Clostridium difficile-associated diarrhoea (CDAD), but their effectiveness depends on both strain and dose. There are few data on nutritional interventions to control AAD/CDAD in the spinal cord injury (SCI) population. The present study aimed to assess (1) the efficacy of consuming a commercially produced probiotic containing at least 6·5 × 10⁹ live Lactobacillus casei Shirota (LcS) in reducing the incidence of AAD/CDAD, and (2) whether undernutrition and proton pump inhibitors (PPI) are risk factors for AAD/CDAD. A total of 164 SCI patients (50·1 (sd 17·8) years) with a requirement for antibiotics (median 21 d, range 5-366) were randomly allocated to receive LcS (n 76) or no probiotic (n 82). LcS was given once daily for the duration of the antibiotic course and continued for 7 days thereafter. Nutritional risk was assessed by the Spinal Nutrition Screening Tool. The LcS group had a significantly lower incidence of AAD (17·1 v. 54·9%, P

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KW - Hospitalization

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KW - Treatment Outcome

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