A mathematical model of the indirect effects of rotavirus vaccination

T. Van Effelterre; M. Soriano-Gabarro; S. Debrus; E. Claire Newbern; J. J. Gray

doi:10.1017/S0950268809991245

A mathematical model of the indirect effects of rotavirus vaccination

T. Van Effelterre, M. Soriano-Gabarro, S. Debrus, E. Claire Newbern, J. J. Gray

Norwich Medical School

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39 Citations (Scopus)

Abstract

Rotavirus (RV) infections progressively confer natural immunity against subsequent infection. Similarly to natural infection, vaccination with a live attenuated vaccine potentially reduces RV transmission and induces herd protection. A mathematical transmission model was developed to project the impact of a vaccination programme on the incidence of RV infection and disease for five countries in the European Union. With vaccination coverage rates of 70%, 90% and 95% the model predicted that, in addition to the direct effect of vaccination, herd protection induced a reduction in RV-related gastroenteritis (GE) incidence of 25%, 22% and 20%, respectively, for RV-GE of any severity, and of 19%, 15%, and 13%, respectively, for moderate-to-severe RV-GE, 5 years after implementation of a vaccination programme.

Original language	English
Pages (from-to)	884-897
Number of pages	14
Journal	Epidemiology and Infection
Volume	138
Issue number	6
DOIs	https://doi.org/10.1017/S0950268809991245
Publication status	Published - Jun 2010

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10.1017/S0950268809991245

Cite this

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title = "A mathematical model of the indirect effects of rotavirus vaccination",

abstract = "Rotavirus (RV) infections progressively confer natural immunity against subsequent infection. Similarly to natural infection, vaccination with a live attenuated vaccine potentially reduces RV transmission and induces herd protection. A mathematical transmission model was developed to project the impact of a vaccination programme on the incidence of RV infection and disease for five countries in the European Union. With vaccination coverage rates of 70%, 90% and 95% the model predicted that, in addition to the direct effect of vaccination, herd protection induced a reduction in RV-related gastroenteritis (GE) incidence of 25%, 22% and 20%, respectively, for RV-GE of any severity, and of 19%, 15%, and 13%, respectively, for moderate-to-severe RV-GE, 5 years after implementation of a vaccination programme.",

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AU - Soriano-Gabarro, M.

AU - Debrus, S.

AU - Claire Newbern, E.

AU - Gray, J. J.

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AB - Rotavirus (RV) infections progressively confer natural immunity against subsequent infection. Similarly to natural infection, vaccination with a live attenuated vaccine potentially reduces RV transmission and induces herd protection. A mathematical transmission model was developed to project the impact of a vaccination programme on the incidence of RV infection and disease for five countries in the European Union. With vaccination coverage rates of 70%, 90% and 95% the model predicted that, in addition to the direct effect of vaccination, herd protection induced a reduction in RV-related gastroenteritis (GE) incidence of 25%, 22% and 20%, respectively, for RV-GE of any severity, and of 19%, 15%, and 13%, respectively, for moderate-to-severe RV-GE, 5 years after implementation of a vaccination programme.

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