A mild procedure for the production of secondary amines from oximes and benzisoxazoles

Mark Searcey; Sukhwant S. Grewal; Fiorenza Madeo; Petros G. Tsoungas

doi:10.1016/s0040-4039(03)01623-x

A mild procedure for the production of secondary amines from oximes and benzisoxazoles

Mark Searcey, Sukhwant S. Grewal, Fiorenza Madeo, Petros G. Tsoungas

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

-2-Hydroxybenzaldoximes are reduced under mild conditions of ammonium formate/Pd-C in methanol to give secondary amines. Benzisoxazoles react under the same mild conditions to give the same products. A possible mechanism is suggested, involving the intermediacy of the benzisoxazole in the oxime conversion. (C) 2003 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	6745-6747
Number of pages	3
Journal	Tetrahedron Letters
Volume	44
Issue number	35
DOIs	https://doi.org/10.1016/s0040-4039(03)01623-x
Publication status	Published - 2003

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10.1016/s0040-4039(03)01623-x

Cite this

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title = "A mild procedure for the production of secondary amines from oximes and benzisoxazoles",

abstract = "-2-Hydroxybenzaldoximes are reduced under mild conditions of ammonium formate/Pd-C in methanol to give secondary amines. Benzisoxazoles react under the same mild conditions to give the same products. A possible mechanism is suggested, involving the intermediacy of the benzisoxazole in the oxime conversion. (C) 2003 Elsevier Ltd. All rights reserved.",

author = "Mark Searcey and Grewal, {Sukhwant S.} and Fiorenza Madeo and Tsoungas, {Petros G.}",

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T1 - A mild procedure for the production of secondary amines from oximes and benzisoxazoles

AU - Searcey, Mark

AU - Grewal, Sukhwant S.

AU - Madeo, Fiorenza

AU - Tsoungas, Petros G.

PY - 2003

Y1 - 2003

N2 - -2-Hydroxybenzaldoximes are reduced under mild conditions of ammonium formate/Pd-C in methanol to give secondary amines. Benzisoxazoles react under the same mild conditions to give the same products. A possible mechanism is suggested, involving the intermediacy of the benzisoxazole in the oxime conversion. (C) 2003 Elsevier Ltd. All rights reserved.

AB - -2-Hydroxybenzaldoximes are reduced under mild conditions of ammonium formate/Pd-C in methanol to give secondary amines. Benzisoxazoles react under the same mild conditions to give the same products. A possible mechanism is suggested, involving the intermediacy of the benzisoxazole in the oxime conversion. (C) 2003 Elsevier Ltd. All rights reserved.

U2 - 10.1016/s0040-4039(03)01623-x

DO - 10.1016/s0040-4039(03)01623-x

M3 - Article

VL - 44

SP - 6745

EP - 6747

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 35

ER -