A Naturally Occurring Inhibitory Agent from Hypericum sampsonii. with Activity Against Multidrug-Resistant Staphylococcus aureus     .

Zhi Yong Xiao; Winnie Ka Po Shiu; Yi Han Zeng; Qing Mu; Simon Gibbons

doi:10.1080/13880200701739405

A Naturally Occurring Inhibitory Agent from Hypericum sampsonii. with Activity Against Multidrug-Resistant Staphylococcus aureus .

Zhi Yong Xiao, Winnie Ka Po Shiu, Yi Han Zeng, Qing Mu, Simon Gibbons

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Bioassay-directed fractionation employing a multidrug-resistant (MDR) strain of Staphylococcus aureus. resulted in the isolation of an antibacterial prenyl substituted xanthone derivative (1) named hyperixanthone A from the root of Hypericum sampsonii. Hance (Hyperiaceae). Compound 1 showed promising inhibitory activity against the norfloxacin-resistant S. aureus. strain SA-1199B at a minimum inhibitory concentration (MIC) of 2 μ g/mL (4.3 μ M), wheres the positive standard antibacterial drug norfloxacin showed an MIC of 32 μ g/mL (100 μ M). This strain overexpresses the NorA multidrug efflux transporter, the major characterized drug pump in Staphylococcus aureus.. The activity of this compound against an effluxing strain of S. aureus. is reported here for the first time. Compound 1, together with 1,7-dihydroxyxanthone (2) and 2-hydroxyxanthone (3), were obtained by silica gel column chromatography, and their structures were determined by means of extensive NMR and MS spectra.

Original language	English
Pages (from-to)	250-253
Number of pages	4
Journal	Pharmaceutical Biology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1080/13880200701739405
Publication status	Published - 2008

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10.1080/13880200701739405

http://www.tandfonline.com/doi/full/10.1080/13880200701739405

Cite this

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title = "A Naturally Occurring Inhibitory Agent from Hypericum sampsonii. with Activity Against Multidrug-Resistant Staphylococcus aureus .",

abstract = "Bioassay-directed fractionation employing a multidrug-resistant (MDR) strain of Staphylococcus aureus. resulted in the isolation of an antibacterial prenyl substituted xanthone derivative (1) named hyperixanthone A from the root of Hypericum sampsonii. Hance (Hyperiaceae). Compound 1 showed promising inhibitory activity against the norfloxacin-resistant S. aureus. strain SA-1199B at a minimum inhibitory concentration (MIC) of 2 μ g/mL (4.3 μ M), wheres the positive standard antibacterial drug norfloxacin showed an MIC of 32 μ g/mL (100 μ M). This strain overexpresses the NorA multidrug efflux transporter, the major characterized drug pump in Staphylococcus aureus.. The activity of this compound against an effluxing strain of S. aureus. is reported here for the first time. Compound 1, together with 1,7-dihydroxyxanthone (2) and 2-hydroxyxanthone (3), were obtained by silica gel column chromatography, and their structures were determined by means of extensive NMR and MS spectra.",

author = "Xiao, {Zhi Yong} and Shiu, {Winnie Ka Po} and Zeng, {Yi Han} and Qing Mu and Simon Gibbons",

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journal = "Pharmaceutical Biology",

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T1 - A Naturally Occurring Inhibitory Agent from Hypericum sampsonii. with Activity Against Multidrug-Resistant Staphylococcus aureus .

AU - Xiao, Zhi Yong

AU - Shiu, Winnie Ka Po

AU - Zeng, Yi Han

AU - Mu, Qing

AU - Gibbons, Simon

PY - 2008

Y1 - 2008

N2 - Bioassay-directed fractionation employing a multidrug-resistant (MDR) strain of Staphylococcus aureus. resulted in the isolation of an antibacterial prenyl substituted xanthone derivative (1) named hyperixanthone A from the root of Hypericum sampsonii. Hance (Hyperiaceae). Compound 1 showed promising inhibitory activity against the norfloxacin-resistant S. aureus. strain SA-1199B at a minimum inhibitory concentration (MIC) of 2 μ g/mL (4.3 μ M), wheres the positive standard antibacterial drug norfloxacin showed an MIC of 32 μ g/mL (100 μ M). This strain overexpresses the NorA multidrug efflux transporter, the major characterized drug pump in Staphylococcus aureus.. The activity of this compound against an effluxing strain of S. aureus. is reported here for the first time. Compound 1, together with 1,7-dihydroxyxanthone (2) and 2-hydroxyxanthone (3), were obtained by silica gel column chromatography, and their structures were determined by means of extensive NMR and MS spectra.

AB - Bioassay-directed fractionation employing a multidrug-resistant (MDR) strain of Staphylococcus aureus. resulted in the isolation of an antibacterial prenyl substituted xanthone derivative (1) named hyperixanthone A from the root of Hypericum sampsonii. Hance (Hyperiaceae). Compound 1 showed promising inhibitory activity against the norfloxacin-resistant S. aureus. strain SA-1199B at a minimum inhibitory concentration (MIC) of 2 μ g/mL (4.3 μ M), wheres the positive standard antibacterial drug norfloxacin showed an MIC of 32 μ g/mL (100 μ M). This strain overexpresses the NorA multidrug efflux transporter, the major characterized drug pump in Staphylococcus aureus.. The activity of this compound against an effluxing strain of S. aureus. is reported here for the first time. Compound 1, together with 1,7-dihydroxyxanthone (2) and 2-hydroxyxanthone (3), were obtained by silica gel column chromatography, and their structures were determined by means of extensive NMR and MS spectra.

U2 - 10.1080/13880200701739405

DO - 10.1080/13880200701739405

M3 - Article

VL - 46

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EP - 253

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

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