A near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis

K. S. Leslie; K. Gaffney; C. N. Ross; S. Ridley; T. H. Barker; J. J. Garioch

doi:10.1046/j.1365-2230.2003.01336.x

A near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis

K. S. Leslie, K. Gaffney, C. N. Ross, S. Ridley, T. H. Barker, J. J. Garioch

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Dapsone (4,4'-diaminodiphenyl sulphone) is used for a variety of dermatological conditions including immunobullous diseases and urticarial vasculitis. Side-effects are common and include lethargy, headaches, methaemoglobinaemia and haemolysis. Severe adverse effects are rare but the dapsone hypersensitivity syndrome is well recognized. Symptoms include fever, haemolytic anaemia, lymphocytosis and hepatitis. We report a near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis. This diagnosis should be remembered in any patient who becomes unwell whilst taking dapsone.

Original language	English
Pages (from-to)	496-498
Number of pages	3
Journal	Clinical and Experimental Dermatology
Volume	28
Issue number	5
DOIs	https://doi.org/10.1046/j.1365-2230.2003.01336.x
Publication status	Published - Sep 2003

Keywords

Anti-Inflammatory Agents, Non-Steroidal/adverse effects
Dapsone/adverse effects
Drug Hypersensitivity/etiology
Female
Humans
Middle Aged
Necrosis
Urticaria/drug therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1046/j.1365-2230.2003.01336.x

Cite this

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title = "A near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis",

abstract = "Dapsone (4,4'-diaminodiphenyl sulphone) is used for a variety of dermatological conditions including immunobullous diseases and urticarial vasculitis. Side-effects are common and include lethargy, headaches, methaemoglobinaemia and haemolysis. Severe adverse effects are rare but the dapsone hypersensitivity syndrome is well recognized. Symptoms include fever, haemolytic anaemia, lymphocytosis and hepatitis. We report a near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis. This diagnosis should be remembered in any patient who becomes unwell whilst taking dapsone.",

keywords = "Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Dapsone/adverse effects, Drug Hypersensitivity/etiology, Female, Humans, Middle Aged, Necrosis, Urticaria/drug therapy",

author = "Leslie, {K. S.} and K. Gaffney and Ross, {C. N.} and S. Ridley and Barker, {T. H.} and Garioch, {J. J.}",

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AU - Leslie, K. S.

AU - Gaffney, K.

AU - Ross, C. N.

AU - Ridley, S.

AU - Barker, T. H.

AU - Garioch, J. J.

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AB - Dapsone (4,4'-diaminodiphenyl sulphone) is used for a variety of dermatological conditions including immunobullous diseases and urticarial vasculitis. Side-effects are common and include lethargy, headaches, methaemoglobinaemia and haemolysis. Severe adverse effects are rare but the dapsone hypersensitivity syndrome is well recognized. Symptoms include fever, haemolytic anaemia, lymphocytosis and hepatitis. We report a near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis. This diagnosis should be remembered in any patient who becomes unwell whilst taking dapsone.

KW - Anti-Inflammatory Agents, Non-Steroidal/adverse effects

KW - Dapsone/adverse effects

KW - Drug Hypersensitivity/etiology

KW - Female

KW - Humans

KW - Middle Aged

KW - Necrosis

KW - Urticaria/drug therapy

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DO - 10.1046/j.1365-2230.2003.01336.x

M3 - Article

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JO - Clinical and Experimental Dermatology

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